The Relationship Between Dietary Inflammatory Index And Cardiometabolic Disease Among Rural Residents In Ili,Xinjiang

Objective: To analyze the relationship between Dietary Inflammatory Index(DII)and Cardiometabolic diseases.we calculated and analyzed whether DII could be used to evaluate the dietary inflammatory potential of rural population in Ili,Xinjiang,and to find out how the DII effect cardiometabolic diseases.Methods: Based on the baseline survey of“Xinjiang multi-ethnic cohort study” in Ili,questionnaire survey,dietary survey,physical measurement,and fasting blood collection were carried out for the subjects.Semi-quantitative food frequency questionnaire was used for dietary survey.According to the semi-quantitative food frequency questionnaire,the average daily intake of each nutrients/foods was obtained,the DII scores of each nutrients/food were calculated,and the DII scores were summed.Finally,according to the quartile of DII scores,the subjects were divided into Q1 group,Q2 group,Q3 group and Q4 group,in which Q4 group represented the most pro-inflammatory group and Q1 represents the most anti-inflammatory group.Generalized linear model(GLM)was used to analyze the difference of serum inflammatory cytokines between group Q1 and group Q4 after logarithmic transformation.Logistic regression analysis was used to analyze the relationship between DII and Cardiometabolic diseases after adjusting for confounding factors.Logistic regression analysis can only be used for single outcome variable analysis,so BN was used to model the causal relationship between DII and cardiometabolic diseases,and to inference causal effect.Results: A total of 6577 subjects were investigated in this study.The prevalence of Cardiometabolic diseases in the study population was 38.63%,37.08%,58.16%,19.60%,20.45%,30.67%,28.60%,37.65%,14.34%,4.88%,respectively,for overweight,obesity,abdominal obesity,low HDL,high LDL,high TC,high TG,hypertension,T2DM,and self-reported cardiovascular diseases.Compared with Q1 group,the serum inflammatory cytokines concentrations of 13 kinds of serum inflammatory cytokines,including CRP,IL-6 and TNF-α2,were significantly increased in Q4 group except for MCP-1.Multivariate adjusted Logistic regression analysis showed that compared with group Q1,the risk of overweight,abdominal obesity,higher TG,lower HDL,higher LDL,hypertension and T2DM were significantly increased in group Q4.The DAG of BN showed that DII directly affected the occurrence of abdominal obesity,hypertension,and high LDL,but had no direct causal relationship with other cardiometabolic diseases;The results of causal reasoning showed that compared with group Q1,the risk of abdominal obesity,hypertension and higher LDL in group Q4 increased by 11.12%,44.07% and 59.23% respectively,and the risk of higher TG,lower HDL and higher T2DM increased by 12.57%,14.98% and 23.63% respectively;The results of intercausal reasoning showed that about 55% of the effect between DII and T2DM was mediated by blood pressure,and about 45% by LDL.Conclusion: The DII calculated in this study can reflect the influence of diet on the inflammatory state of the body.BN reveal the direct and indirect causality between DII and various Cardiometabolic diseases using graphical visualization method.A high DII score is associated with an increased risk of cardiometabolic diseases.Controlling the influence of DII on cardiometabolic diseases depends on controlling the population’s waist circumference,blood pressure,and LDL.