Evidence Summary For Multicomponent Nonpharmacological Management Of Delirium And Subsyndromal Delirium In Adult Intensive Care Units

Background:Delirium and Subsyndrome Delirium are acute brain dysfunction syndromes with the same symptom and similar risk factors.Both of them have high incidence in ICU,causing adverse effects and are becoming a great burden of health care system.predicting,screening,preventing and treating delirium and SSD have become the key indicators and factors of the quality of care in ICU for the last couple years.While pharmacological options are not suggested,researchers have been dedicated to reveal whether multicomponent nonpharmacological interventions focusing on the adjustable risk factors benefit.However,recommendations and research outcomes differ.Evidence which comprehensively summarize validated evidence are lack and necessary.Transparency and validity of evidence summary process can be increased within the combination of Knowledge to Action model’s evidence summary process and Joanna Brigges Institute’s evidence pre-ranking and evidence recommendation system.Thus to form a continuity and scientific basis for knowledge translation and delirium management.Objectives:Summarizing the relevant evidence of non-pharmacological management of delirium and Subsyndromal delirium for critically ill adults,through KTA evidence summary and JBI evidence classification system,thus to promote knowledge translation,optimize delirium management and improve patient outcome.Methods:The evidence summary process in this research was guided by the evidence summary process and JBI evidence pre classification and evidence recommendation system We searched and selected articles via English websites of guidelines and related societies such as G-I-N,WHO,NICE,RNAO,SIGN,MINDS,ACPG,Yimaitong and AGS,ADS,BGS,EDA,AWMF,ANZSGM.As well as databases like JBI,PubMed,EMBASE,Wanfang Data,CNKI,Sinomed,and clinical trial registration website ICTRP,Cochrane CENTRAL.Grey literature was searched so as references in included articles to expand the searching scope.After including articles that meet the inclusion critiria of publication year,target population and research type,3 researchers independently appraisal the articles using validated tools.And qualitative evidence synthesis was formed to implicated the best practice of nonpharmacological management of delirium and subsyndromal delirium in adult critically ill adult patients.Results:A total of 52 documents were included,and the evaluation results showed that the quality of the included documents was high.47 pieces of evidences and recommendations including delirium risk prediction,screening,prevention and treatment were generated.Conclusions:Based on the evidence summary process,the evidence summary for nonpharmacological management of delirium and subsyndromal delirium is of scientific and feasible,which can later be imported to clinical practice to further verify in both effectiveness and cost-effectiveness.