Quantitative Analysis Methods Of Brain Structure And Function In Patients With Early Parkinson’s Disease

The quantitative analysis of magnetic resonance brain images is an important means of computer-aided diagnosis and monitoring of Parkinson’s Disease(PD).Due to the complexity of the overall structures of the brain and the diversity of pathological changes in PD,analysis of single or local structures does not meet the needs of disease diagnostic analysis.In this paper,a complete framework based on global brain statistical analysis was used to observe the changes of cortical and subcortical structures in early PD patients,and to study the differences of gray matter and white matter fibers between early Parkinson’s disease patients and normal controls.Main contents are as follows:1.From the perspective of morphological analysis,the T1-weighted structure images were analyzed by surface-based morphometry(SBM).The differences of cortical thickness,cortical surface and subcortical structure volume between early PD patients and normal controls were compared.The difference in volume.The experimental results of 38 early PD patients and 32 healthy subjects showed that the cortical thickness of several local cortical areas including the temporal lobe,parietal lobe and insular lobe was significantly thinner in the early PD patients.The volume of the subcortical structure of the lateral hippocampus and the right accumbens was significantly reduced,and the difference was statistically significant(P<0.05).The results indicate that cortical thickness can be used as a marker to evaluate preclinical diagnosis and progression of early PD patients.2.From the perspective of functional analysis,diffusion tensor imaging(DTI)images were analyzed by Tract-based spatial statistics(TBSS).Fractional anisotropy(FA),mean diffusivity(MD),axial diffusion(AD)and radial diffusivity(RD)were used to compare 38 patients with early PD and 32 healthy subjects.The results showed that there were significant reductions in FA values in multiple local areas including corpus callosum,temporal lobe and parietal white matter,and the difference was statistically significant(P<0.05).There was an increase in local MD,AD,and RD values,but no statistically significant areas were detected.The results indicate that the FA value can be used as an evaluation index for functional changes in the brain region of patients with early PD,and is used for quantitative assessment of white matter abnormalities.