Study On The Clinical Correlation Between Fetuin A And Aortic Valve Calcification

【Background】Calcific aortic valve disease(CAVD)is a group of diseases in which fibrosis and sclerosis of aortic valve and surrounding tissues are the main changes,and aortic stenosis(AS)is the main functional impairment.At present,CAVD is considered to be an active and progressive pathological process,involving lipid infiltration,chronic inflammatory reaction,osteoblast activation and other pathological conditions.Fetuin A,A glycoprotein synthesized and secreted by the liver,is involved in the regulation of lipid metabolism,calcium and phosphorus metabolism,insulin resistance and inflammatory cascade,and is closely related to the occurrence and development of cardiovascular diseases.There are still some controversies on the mechanism of Fetuin A’s involvement in the development of CAVD,and the clinical evidence is inconsistent.【Objective】To study the clinical correlation between Fetuin A and CAVD.【Methods】1、197 cases of non-cavd patients and 200 cases of CAVD patients were selected;2、Enzyme-linked immunosorbent assay(ELISA)was used to detect the serum Fetuin A concentration;3、Statistical methods:the measurement data were expressed by the median,and the counting data were expressed by n(%).Nonparametric mann-whitney U test was used to compare the differences between measurement data sets,and 2-by-2 chi-square test was used to compare the differences between counting data sets.Propensity score matching(PSM)was used to match numerous confound factors with statistical differences.Independent risk factor analysis was performed by binary logistic regression test.【Results】1、The serum Fetuin A concentration in CAVD group[0.132(0.027-0.152)mg/m L]was significantly higher than that in non-cavd group[0.0745(0.026-0.101)mg/m L,P<0.000].2、Mantel-Haenszel Chi-square test results showed that there was a linear correlation between CAVD and Fetuin A concentration fraction.(?~2=14.616,P<0.000).Pearson’s results showed a positive correlation between CAVD and Fetuin A concentration fraction(R=0.334,P<0.000);3、The results of Restricted cubic spline(RCS)showed that when Fetuin A concentration was>0.0755mg/m L,the risk of CAVD increased with the increase of serum Fetuin A concentration.CAVD risk decreased when serum Fetuin A concentration<0.0755mg/m L.【Conclusion】Fetuin A may be associated with CAVD disease,which is closely related to serum Fetuin A concentration and may have A pathogenic threshold.When the serum Fetuin A concentration was higher than the threshold,the risk of CAVD increased with the increase of the serum Fetuin A concentration,and the control of Fetuin A concentration within A certain range can reduce the risk of CAVD.Its clinical application value and specific mechanism of action need to be further studied.