Value Of Preoperative SII And B7-H3 In Prediction Of Distant Metastasis After Radical Resection For Stage Ⅱ-Ⅲ Colorectal Cancer

ObjectiveTo investigate the value of preoperative SII and B7-H3 in prediction of distant metastasis after radical resection in stage Ⅱ-Ⅲ colorectal cancer.Methods1 We selected 231 patients developed Colorectal Cancer in stage Ⅱ-Ⅲ who had radical resection in the Second Affiliated Hospital of Fujian Medical University from June 2012 to February 2015.55 patients with postoperative distant metastasis(group A)were selected,and 54 patients(group B)from 176 patients without postoperative distant metastasis were randomly chosen as well.We collected postoperative cancer tissue wax blocks and blood routine results examed within one week before the operation from the above patients,and recorded the relevant clinicopathological features.2 The systemic immune inflammation index was calculated by using the formula "SII= platelets×neutrophils/lymphocytes",while the expression level of B7-H3 in tumor tissues were detected by immunohistochemistry.The relationship between different levels of preoperative SII,B7-H3 and clinicopathological characteristics of CRC patients,the correlation between B7-H3 and preoperative SII,and the risk factors of CRC postoperative distant metastasis were analyzed retrospectively,to explore the predictive value of preoperative SII and B7-H3 in prediction of CRC postoperative distant metastasis.Results1 There’s no significant diffirence between the level of preoperative SII and sex,age,tumor size and tumor location,depth of tumor invasion(P>0.05).2 The level of preoperative SII was positively correlated with vascular cancer embolus,lymphatic metastasis,tumor stage and postoperative distant metastasis(P<0.05).3 There’s no significant correlation between B7-H3 and sex,age,tumor size,tumor location,vascular cancer embolus,lymphatic metastasis and tumor staging(P>0.05).4 The high level of B7-H3 was positively correlated with depth of tumor invasion and postoperative distant metastasis(P<0.05).5 Preoperative SII was positively correlated with B7-H3(P<0.05).6 Preoperative SII,B7-H3,vascular cancer embolus,and tumor stage all can be used as independent risk factors for postoperative distant metastasis after radical resection for CRC patients in stage Ⅱ-Ⅲ(P<0.05).7 The occurence rate of postoperative distant metastasis after radical resection in CRC patients was significantly higher with high B7-H3 expression and high level of preoperative SII than those with single high expression or double low expressions.Conclusions1 Preoperative SII has a positive correlation with vascular cancer embolus,lymphatic metastasis,tumor stage and postoperative distant metastasis for CRC patients in stage Ⅱ-Ⅲ.The preoperative high SII level may be an independent risk factor for distant metastasis after radical resection for CRC patients in stage Ⅱ-Ⅲ,which perhaps has potential value in prediction of postoperative distant metastasis after radical resection for CRC patients in stage Ⅱ-Ⅲ.2 B7-H3 has a positive correlation with depth of tumor invasion and postoperative distant metastasis for CRC patients in stage Ⅱ-Ⅲ.The high level of preoperative SII may be an independent risk factor of distant metastasis after radical resection for CRC patients in stage Ⅱ-Ⅲ,which perhaps has potential value for postoperative distant metastasis after radical resection for CRC patients in stage Ⅱ-Ⅲ.3 The combined analysis of B7-H3 and SII can more effectively predict postoperative metastasis after radical resection for CRC patients in stage Ⅱ-Ⅲ.