| ObjectiveThrough Pittsburgh Sleep Index Scale(PSQI),Traditional Chinese Medicine Constitution Scale,Short Form of Health Survey(SF-36 Scale),Fatigue Scale(FS-14 Scale)and other multidimensional evaluations,the clinical efficacy of Shuxin Anshen Ointment in treating insomnia of yang-deficiency and qi-stagnation teachers is evaluated,which provides a safe and reliable basis for further clinical application of Shuxin Anshen Ointment.MethodsA randomized,double-blind placebo-controlled design was used in the study.The subjects of the study were teachers with insomnia and yang deficiency and qi depression.A total of 96 patients were included in the analysis,and 48 in the treatment group and 48 in the control group.Patients in the treatment group were treated with Shuxin Anshen Ointment orally,while patients in the control group were treated with Shuxin Anshen Ointment placebo orally for 4 weeks.The therapeutic effects of the two groups were compared.Results1.PSQI total score and PSQI reduction rate:after 4 weeks of treatment,the total score of PSQI of the general population,yang deficiency constitution and qi depression constitution group decreased,and there was a significant difference(P<0.05)in the total score of PSQI between cream group and placebo group,and there was a significant difference(P<0.05)in the total score of PSQI before and after treatment in the two groups,indicating that Shuxin Anshen Ointment and Shuxin Anshen Ointment placebo have therapeutic effects on the sleep quality of the general population and the two constitution groups in a short period of treatment.There is a significant difference in PSQI reduction rate between the two groups(P<0.05)combined with the overall and qi stagnation constitution teacher gr oups.However,the total score of PSQI in yang deficiency teacher groups is reduced after tre.atment,but there is no significant difference in PSQI reduction rate between the two groups(P>0.05).This indicates that Shuxin Anshen Ointment is superior to placebo in improving sleep quality,and the sleep improvement effect in short-term treatment is superior to yang deficiency teacher groups.2.Subjective sleep condition:on the whole,there is significant difference in subjective sleep duration,subjective sleep time and subjective sleep efficiency between the two groups before and after treatment(P<0.05),but there is no significant difference in the comparison between the two groups and the difference between the two groups before and after treatment(P>0.05),indicating that the cream group and the placebo group have curative effects on the overall subjective sleep duration,subjective sleep time and subjective sleep efficiency,but there is no difference in curative effects,and the results of the group of teachers with qi depression are consistent with the overall subjective sleep condition.However,in the group of teachers with yang deficiency constitution,there is a significant difference(P<0.05)in the subjective sleep duration between the two groups before and after treatment.there is no significant difference(P>0.05)in the comparison between the two groups and the difference between the two groups before and after treatment,indicating that the herbal paste group and the placebo group have curative effect on the subjective sleep duration of yang deficiency constitution in short-term treatment,but there is no difference in curative effect.The subjective sleep time and subjective sleep efficiency of the placebo group have significant difference(P<0.05)before and after treatment,while the subjective sleep time of the cream group before and after treatment and the difference between the two groups before and after treatment have no significant difference(P>0.05),suggesting that the subjective sleep time and subjective sleep efficiency of the placebo group in yang deficiency constitution group have difference after short-term treatment..3.PSQI scoring factors:in general,the scores of all scoring factors(except hypnotic drugs)before and after treatment in the two groups have significant differences(P<0.05),and the scores of sleep quality factors and daytime dysfunction factors after treatment between the two groups have significant differences(P<0.05),while the differences of sleep quality,sleep time,sleep disorder,hypnotic drugs and daytime dysfunction before and aft.er treatment between the two groups have significant differences(P<0.05).It indicates that the two groups have ourative effects on the overall sleep quality,sleep time,sleep time,sleep efficiency,sleep disorder and daytime dysfunction index after treatment in short-term treatment,and the curative effects of the paste group and placebo group are different in sleep quality,sleep time,sleep disorder,hypnotic drugs and daytime dysfunction.For yang deficiency constitution groups,the scores of sleep quality,sleep time,sleep efficiency,sleep disorder and daytime dysfunction in the two groups before and after treatment are significantly different(P<0.05),while the scores of sleep quality and daytime dysfunction before and after treatment are significantly different(P<0.05),and the scores of daytime dysfunction between the two groups after treatment are signifi cantly different(P<0.05).However,the scores of sleep time before and after treatment in the placebo group were significantly different(P<0.05),while the scores before and after treatment in the treatment group and the differences between the scores before and after treatment in the two groups were not significantly different(P>0.05).It is suggested that in the short-term treatment,the herbal paste group and the placebo group have curative effects on sleep quality,sleep time,sleep efficiency,sleep disorder and daytime dysfunction for the yang deficiency constitution group,and the curativeeffect of the herbal paste group is better than that of the placebo group in sleep quality and daytime dysfunction.For qi stagnation constitution,the scores of sleep quality,sleep time,sleep time,sleep disorder and daytime dysfunction before and after treatment in the two groups are significantly different(P<0.05),while the scores of sleep efficiency before and after treatment in the treatment group are significantly different(P<0.05),while the scores before and after treatment in the control group are not significantly different(P>0.05).The scores of sleep quality and daytime dysfunction after treatment between the two groups are different(P<0.05),while the scores of sleep quality,sleep time,sleep disorder and daytime dysfunction before and after treatment between the two groups are significantly different(P<0.05),suggesting that the two groups have therapeutic effects on sleep quality,sleep time,sleep time,sleep disorder and daytime dysfunction indicators for the group with qi stagnation constitution,and the herbal paste group is hetter than the placebo group in improving sleep quality,sleep time,sleep disorder and daytime dysfunction of yang deficiency constitution.4.Quality of life:in general,the scores of physiological function and health changes before and after treatment in the two groups have significant difference(P<0.05),and the differences between the two groups before and after treatment have significant difference(P<0.05);At the same time,the general health status,energy and mental health scores in the cream group before and after treatment have significant differences(PC 0.05),while there is no significant difference(P>0.05)in the placebo group before and after treatment,but there is significant difference(P<0.05)between the two groups before and after treatment.It is suggested that the therapeutic effects of the two groups on physiological function,general health status,energy,mental health and health change indexes are different,and the cream group is superior to the placebo group.For yang deficiency constitution group,the scores of physiological function and health changes before and after treatment in the two groups have significant differences(P<0.05),and the general health status and energy scores have significant differences(P<0.05)before and after treatment in the cream group,while there is no difference(P>0.05)before and after treatment in the placebo group.The difference of scores before and after treatment between the two groups combined with energy has significant difference(P=0.005).This shows that in short-term treatment,placebo group has therapeutic effect on physiological function and health changes for yang deficiency constitution group,while cream group has therapeutic effect on physiological function,general health status,energy and health changes,and the therapeutic effect on energy is better than placebo group.For the group with qi stagnation constitution,the scores of physiological functions before and after treatment in the two groups are significantly different(P<0.05),and the scores of general health status,mental health and health changes are significantly different(P<0.05)before and after treatment in the cream group,while there is no difference(P>0.05)before and after treatment in the placebo group.The difference of scores of physiological function,general health status,mental health and health changes before and after treatment were significantly different between groups(P<0.05).This shows that in the short-term treatment,the two groups of treatment have an improvement on physiological function indexes for the group with qi stagnation constitution,while the herbal paste group has an improvement on general health status,mental health and health changes,and the curative effect on improving physiological function,general health status,mental health and health changes is better than that of the placebo group.5.Fatigue:on the whole,the total scores of physical fatigue and fatigue before and after treatment in the two groups have significant differences(P<0.05),while the scores of these two items have significant differences(P<0.05)between the groups after treatment and between the groups before and after treatment.The scores of mental fatigue are different(P<0.05)in the intra-group comparison before and after treatment in the cream group and the difference between the two groups before and after treatment,but there is no difference(P>0.05)in the corresponding comparison in the placebo group.It is suggested that in the short-term treatment,the two groups of treatment have an improvement effect on physical fatigue and fatigue total score index on the whole,and the herbal paste group also has an improvement effect on mental fatigue,and the curative effect of herbal paste group on physical fatigue,mental fatigue and fatigue total score is better than that of placebo group.For yang deficiency constitution group,the scores of body fatigue and fatigue total scores before and after treatment in the two groups have significant difference(P<0.05),while the score comparison between the two groups after treatment and the score difference between the two groups before and after treatment have no significant difference(P>0.05);At the same time,there is no obvious difference in all aspects of mental fatigue(P>0.05).It is suggested that in the short-term treatment,the two groups of treatment can improve physical fatigue and fatigue total score for yang-deficiency physique groups,but there is no obvious difference in curative effect between the two groups.For the group with qi stagnation constitution,there is significant difference in the scores of physical fatigue and fatigue before and after treatment in the two groups(P<0.05).at the same.time,there is significant difference in the scores of these two items between the groups after treatment and the differences between the groups before and after treatment(P<0.05);The scores of mental fatigue had difference(P<0.05)in the group before and after treatment in the herbal paste group,but there was no difference(P>0.05)in the corresponding comparison in the placebo group.It is suggested that the treatment of the two groups can improve the physical fatigue and fatigue total score index of the group with qi stagnation constitution,and the curative effect of the herbal paste group on physical fatigue and fatigue total score is better than that of the placebo group,while the herbal paste group can also improve the mental fatigue index of the group with qi stagnation constitution.6.Physically:after 4 weeks of treatment,the overall constitution of some patients has changed,and the constitution ratio of constitution types between the two groups has significant difference(P=0.049),indicating that the therapeutic effect of herbal paste group on the two constitutions is different from that of placebo group.The constitution ratio of constitution types of yang-deficiency constitution groups after treatment is significantly different(P=0.033),suggesting that the curative ef fect of herbal paste group on yang-deficiency constitution is different from placebo group.There was no significant difference in the constitution ratio of constitution types between the two groups after treatment(P>0.05),suggesting that there was no significant difference in the curative effect of herbal paste group on qi stagnation constitution and placebo group.ConclusionShuxin Anshen Ointment has obviously improved subjective sleep quality in short-term treatment for insomnia patients of yang-deficiency and qi-depression teachers,and the curative effect of qi-depression constitution group is better than that of yang-deficiency constitution group.It can also improve the quality of life of teachers with yang deficiency and qi depression,especially in terms of physiological function and health change indicators.It can also improve the fatigue state of teachers with yang deficiency and qi depression,in which body fatigue and fatigue total score index are obviously improved,and it has obvious curative effect on mental fatigue of the general and qi depression groups.At the same time,Shuxin Anshen Ointment has the effect of correcting the biased constitution for yang deficiency and qi depression groups.Therefore,Shuxin Anshen Ointment is of clinical significance in promoting the treatment of insomnia disorder among teachers with yang deficiency and qi stagnation. |
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