| Objective: To explore the relationship between preoperative fibrinogen to prealbumin ratio(FPR)and clinicopathological characteristics and prognosis of patients with epithelial ovarian cancer,and to provide a reference for the clinical treatment and prognosis of epithelial ovarian cancer.Methods: The clinical and pathological data and follow-up data of 93 patients with epithelial ovarian cancer who underwent ovarian tumor cell depletion in Guang Xi medical university affiliated tumor hospital from January2015 to June 2018 were collected,and the optimal cutoff value of FPR was calculated by establishing a ROC curve and according to The best cutoff value is divided into high FPR group and low FPR group.The relationship between FPR and serological indicators and clinical pathology of epithelial ovarian cancer patients is analyzed.Kaplan-Meier is used to draw survival curves.The difference analysis is performed by log-rank test(log-rank test),using Cox regression model to analyze the factors affecting overall survival(OS)and progression free survival(PFS).Results:1.Receiver operating characteristic curve results of FPR on the prognosis of epithelial ovarian cancer: ACU is 0.747,cutoff is 19.0766,according to this,FPR is divided into two groups(high value group> 19.07,and low value group≤ 19.07).2.The platelet,neutrophil,monocyte,neutrophil to lymphocyte ratio(NLR)and platelet to lymphocyte ratio(PLR)levels in the high-value FPR group were higher than those in the low-value group,while albumin,lymphocytes,and prognosis nutrition index(PNI)level was lower than the low value group,and the difference was statistically significant(P <0.05).3.FPR was positively correlated withplatelet,neutrophil,monocytes,neutrophil to lymphocyte ratio(NLR),platelet to lymphocyte(PLR)(P<0.05),and negatively correlated with albumin,lymphocytes,and prognostic nutrition index(PNI)(P<0.05).4.The correlation between preoperative FPR and age,tumor size,CA125 level,FIGO stage,pathological type,and lymph node metastasis in patients with epithelial ovarian cancer was not statistically significant(P>0.05).Preoperative FPR and tumor histological grade,omentum metastasis,ascites,postoperative residual lesion are closely related,and the differences are statistically significant.5.The 1-year and 3-year overall survival rates of patients with high FPR were 89.6% and 45.6% respectively,while those of patients with low FPR were97.4% and 68.1% respectively.Single factor analysis showed that FPR,FIGO stage,lymph node metastasis,omental metastasis and residual lesions were risk factors affecting the overall survival time of patients with epithelial ovarian cancer.Multivariate analysis showed that only preoperative FPR(HR= 4.45,95%CI=1.772-11.18,P=0.001)was an independent risk factor affecting the overall survival time of patients.Patients with epithelial ovarian cancer with high FPR had poor prognosis.6.The 1-year and 3-year total progression free survival rates of patients with high FPR were 76.3% and 25.1%,respectively,while the 1-year and3-year total progression-free survival rates of patients with low FPR before surgery were 86.7% and 40.1%,respectively.Single factor analysis showed that FPR,CA125 level,FIGO stage,pathological type,histological grade,lymph node metastasis,omental metastasis and residual lesions were risk factors affecting progression-free survival of patients with epithelial ovarian cancer.Multivariate analysis showed that lymph node metastasis(HR=2.466,95%CI:1.160-5.242,P=0.019)and residual lesions(HR=3.757,95%CI:1.779-7.934,P=0.001)were independent risk factors for progression-free survival of patients.Conclusion:1.Preoperative FPR is closely related to histological grade of epithelial ovarian cancer,omentum metastasis,ascites,and residual lesions.2.The overall survival time of patients with epithelial ovarian cancer is related to FPR,staging,lymph node metastasis,omental metastasis and residual lesions.FPR>19.07 is an independent risk factor affecting the overall survival time of patients.Patients with epithelial ovarian cancer with high FPR have poor prognosis.3.The progression free survival of patients with epithelial ovarian cancer is related to FPR,CA125 level,FIGO stage,pathological type,histological grade,lymph node metastasis,omental metastasis and residual lesions.Lymph node metastasis and residual focus are independent risk factors affecting patients’ progression-free survival.4.Whether FPR can be used as a new indicator still requires multi-center,large sample further research. |
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