Clinical Study Of Conbercept Assisted Vitrectomy In The Treatment Of Proliferative Diabetic Retinopathy

OBJECTIVE:To analyze the clinical efficacy of intravitreal injection of Conbercept(IVC)assisted pars plana vitrectomy(PPV)in patients with proliferative diabetic retinopathy(PDR)at different timings before surgery and the effects on intraoperative and postoperative complications.METHODS:A total of 47 eyes of 47 patients with PDR were enrolled in this prospective randomized controlled study.The patients were randomly divided into two groups:the patients who received IVC 2-3days before PPV were assigned to group A(26 eyes of 26 patients);and the patients who received IVC 7-8 days before PPV were assigned to group B(21 eyes of 21patients).The analysis included the operation time,the number of intraoperative bleeding,electrocoagulation,iatrogenic retinal tears,omental incision eyes,silicone oil-filled eyes.The best corrected visual acuity(BCVA)of the two groups were recorded 6 months after PPV.The postoperative complications of the two groups including postoperative vitreous hemorrhage,high intraocular pressure,and incidence of secondary glaucoma were ducumented by the observers.RESULTS:The BCVA measured 6 months after PPV were significantly better than that measured before PPV in both groups(P<0.05),There was no significant difference in BCVA between the two groups(P>0.05).The average operation time of group A was lower than that of group B(73.19±22.78 min vs91±31.36 min,P<0.05),There were no significant difference in the number of intraoperative bleeding,electrocoagulation,iatrogenic retinal tears,omental incision eyes,silicone oil-filled eyes between the two groups(P>0.05).One week after PPV,The incidence of high intraocular pressure in group A was lower than that in group B(group A :4 eyes vs group B:9eyes,P<0.05).6-month post-operative follow-up,No recurrent vitreous hemorrhage occurred in either group,there were no significant difference in the incidence of secondary glaucoma and recurrent retinal detachment between the two groups(P>0.05).CONCLUSION:PDR patients who received IVC2-3days prior to PPV had shorter operation time than patients who received IVC 7-8days prior to PPV.Both groups can improve postoperative visual acuity,and clinical efficacy and safety are basically the same.