Study On The Distribution Regularity Of TCM Constitution And Its Correlation With Syndromes In Patients With Interstitial Lung Disease

Objecti ve:Through the study of TCM constitution and syndromes of patients with interstitial lung disease(ILD),in order to summarize the distribution regularity of constitution and explore the correlation between constitution and syndromes,which will open up new ideas for early prevention,diagnosis and treatment of ILD.Methods:Formulating clinical observation table of TCM constitution and syndromes for patients with interstitial lung disease,The general condition,constitutional factors and syndrome elements of 198 ILD patients who met the inclusion criteria were observed.The quantitative identification software of TCM physique in Qingdao was used to determine the patients’ constitution types,and the TCM syndrome was diagnosed by two TCM doctors with intermediate or above titles.Establish a database,use SPSS21.0 software to process data,summarize the constitution and syndrome distribution regularity of ILD patients,and analyze the correlation between constitution and syndrome.Results:1.Basic information:Among 198 patients with ILD,125 were male(63.13%)and 73 were female(36.87%),the ratio of males to females was 1.71:1;the age was 38-92 years old,with an average of 69.28±11.65 years;the course of disease was 6 months to 10 years,with an average of 3.34±2.30 years.2.Distribution of constitutional types:Yin deficiency(57 cases,28.79%)>phlegm-dampness(46 cases,23.23%)>qi deficiency(37cases,18.69%)>bloody stasis(28 cases,14.14%)>yang deficiency(9cases,4.55%)>peace quality(7cases,3.54%)>Special quality(6cases,3.03%)>dampness-heat quality(5 cases,2.53%)>Qi stagnation(3 cases,1.52%).3.Distribution of TCM syndromes:Yin deficiency with internal heat syndrome(52 cases,26.26%)>phlegm-heat obstructing lung syndrome(43 cases,21.72%)>lung-kidney qi deficiency syndrome(35 cases,17.68%)>phlegm and blood stasis obstruct lung syndrome(29 cases,14.65%)>lung-kidney qi and yin deficiency syndrome(21 cases,10.61%).4.Distribution of syndromes in patients with various constitutional types:Among the yin deficiency patients,the yin deficiency with internal heat syndrome accounted for the highest proportion(61.4%);among the phlegm-dampness patients,the phlegm-heat obstructing lung syndrome accounted for the highest proportion(58.7%);among the blood stasis patients,the phlegm and blood stasis obstruct lung syndrome accounted for the highest proportion(53.57%);among the dampness-heat patients,the phlegm-heat obstructing lung syndrome accounted for the highest proportion(40%);among the peace quality patients,the lung-kidney qi deficiency syndrome accounted for the highest proportion(28.57%);among the special quality patients,the yin deficiency with internal heat syndrome accounted for the highest proportion(50%);among the yang deficiency patients,the lung-kidney qi deficiency syndrome accounted for the highest proportion(55-56%);among the qi deficiency patients;the lung-kidney qi deficiency syndrome accounted for the highest proportion(48.65%);among the qi stagnation patients,the proportion of phlegm-heat obstructing lung syndrome,phlegm-stasis obstructing lung syndrome and lung-kidney qi deficiency syndrome was equal(33.33%).5.Relationship between constitution types and syndromes:The common constitutional types of ILD patients were significantly correlated with syndromes(P<0.05).Patients with yin deficiency were prone to yin deficiency with internal heat syndrome(OR=11.604),followed by lung-kidney qi and yin deficiency syndrome(OR=2.515);Patients with phlegm-dampness constitution are prone to the syndrome of phlegm-heat obstructing the lung(OR=12.079);Patients with qi deficiency tend to have lung-kidney qi deficiency syndrome(OR=8.025),followed by lung-kidney qi and yin deficiency syndrome(OR=1.884).Patients with blood stasis are prone to develop phlegm-stasis obstructing lung syndrome(OR=12.857).Conclusion:1.The incidence of ILD is correlated with the type of patient’s constitution.In ILD patients,the proportion of yin deficiency is the highest,followed by phlegm-dampness,qi deficiency and blood stasis.2.The most common syndromes of ILD patients are Yin deficiency with internal heat syndrome,followed by phlegm-heat obstructing lung syndrome,lung-kidney Qi deficiency syndrome,phlegm and blood stasis obstruct lung syndrome and lung-kidney qi and yin deficiency syndrome.3.There is an intrinsic link between common constitutional types and syndromes in patients with ILD.Patients with yin deficiency are prone to yin deficiencywith internal heat syndrome,followed by lung-kidney qi and yin deficiency syndrome;phlegm-dampness constitution patients are easy to express as phlegm-heat obstructing lung syndrome;patients with qi deficiency are prone to lung-kidney qi deficiency syndrome,followed by lung-kidney qi and Yin deficiency syndrome;Patients with blood stasis tend to show phlegm-stasis obstructing lung syndrome.