The Correlation Between Sjogren’s Syndrome Associated With Interstitial Pneumonia And Tumor Markers Was Discussed From The Aspects Of Dry Bi Which Affects Lung

Objective: To investigate the abnormal elevation of major tumor markers carcinoembryonic antigen(CEA),carbohydrate antigen 199(CA199),carbohydrate antigen 724(CA724),and alpha-fetoprotein(AFP)in patients with Sjogren’s Syndrome-related Interstitial Lung Disease,screening the tumor markers which associated with Sjogren’s Syndrome-related Interstitial Lung Disease,and discuss the correlation between Sjogren’s Syndrome-related Interstitial Lung Disease and syndrome differentiation.Method: The levels of tumor markers(CEA,AFP,CA19-9,CA724)in 32 patients with SS-ILD,191 patients with IPF,and 38 patients with SS were collected for comparative analysis of abnormally elevated tumor markers.Results:1.The age between SS group and SS-ILD group was statistically significant(P<0.05).The sex between SS-ILD group and IPF group was statistically significant(P<0.05).After adjusting for age and gender confounding factors,CEA and CA199 between SS group and SS-ILD group had Statistically significant(P<0.05),AFP and CA724 were not statistically significant (P>0.05).There was no significant difference in CEA,CA199,AFP,and CA724 between SS-ILD group and IPF group(P>0.05).2.Compared with SS patients with CEA level in the first quartile,When the CEA level was in the 4th quantile,the risk of interstitial pneumonia in SS patients increased by 7.8 times.After adjusting for gender and age,the risk increased by 7.45 times(odds ratio(OR)= 7.48,95% confidence interval(CI)=1.597-35.112).Compared with SS patients with CA199 levels in the first quartile,if the CA199 level was in the 2nd,3rd,and 4th queuing,the risk of SS patients with interstitial pneumonia increased by 0.117,0.107,0.107 times,respectively,adjusting gender and age.After that,the risk increased by only0.118,0.108 times in the 3rd and 4th quantiles.3.The AUC predicted by CEA is 0.71(95% CI: 0.583 to 0.836),and the optimal cut-off point is 2.70 ng/m L.The sensitivity and specificity are 62.5% and78.9%,respectively.The predicted AUC was 0.663(95% CI: 0.529-0.797),and the optimal cut-off point was 20.65 U/m L.The sensitivity and specificity were50.0% and 89.5%,respectively.4.Among the tumor markers,only CEA,CA199 and TCM syndrome differentiation were statistically significant(P<0.05).When comparing two groups of TCM syndrome types,it was found that when CEA was increased,there were statistically significant differences between the three groups,namely lung phlegm heat syndrome,qi-yin deficiency syndrome,and syndrome of lung dryness due to yin deficiency.(P<0.05).When CA199 was elevated,there were statistically significant differences between the four groups,namely lung phlegm heat syndrome,qi-yin deficiency syndrome,liver-kidney deficiency syndromeand syndrome of lung dryness due to yin deficiency(P<0.05).Conclusion: Tumor markers in interstitial lung disease,including idiopathic interstitial pneumonia and connective tissue disease-related interstitial pneumonia,such as Sjogren’s Syndrome-related Interstitial Lung Disease discussed in this paper,are relatively common in clinical practice,and the elevated interstitial lung disease rather than connective tissue disease is the cause.There were differences in the levels of tumor markers,such as CEA,CA199,between SS and SS-ILD.The higher the level of tumor markers,the higher the risk of interstitial pneumonia.Tumor markers,such as CEA and CA199,have certain implications for the prevention of SS complicated with interstitial pneumonia,In SS-ILD-patients,increased tumor markers were found in qi-yin deficiency syndrome,phlegm heat yong lung syndrome and yin-deficiency lung dryness syndrome,which could provide guidance for clinical syndrome differentiation and treatment.