Study On The Relationship Between Cerebral Blood Flow Perfusion And Qi Deficiency Syndrome And Disease Progression In Acute Ischemic Stroke

By studying the relationship between Qi deficiency syndrome of apoplexy and cerebral blood flow perfusion and disease progression,the etiology and pathogenesis of Qi deficiency syndrome of apoplexy were explored,and the theoretical basis for the treatment of progressive stroke was provided.Methods:Eighty new stroke patients were selected from Weifang Hospital of Traditional Chinese Medicine from June 2017 to September 2018.According to the scores of Qi deficiency syndrome in the Diagnostic Scale of Ischemic Stroke Syndrome Elements on the day of admission,the patients with acute cerebral infarction who met the inclusion criteria were grouped.Those whose scores of Qi deficiency syndrome were more than 7 were grouped into Qi deficiency group,those whose scores were less than 7 were grouped into non-Qi deficiency group,and the brain deaths of the National Institute of Health were used.Neurological deficits were assessed by the NIHSS scale at admission.Neurological deficits were assessed every 12 hours in early three days,and 24 hours in 4-7 days before admission.An increase of 2or more points in NIHSS scores at any one time within 7 days of admission(the first day of admission)is defined as progress.Comparing the degree of prone to progression between the two groups,comparing the difference of ASL cerebral blood flow around the lesion between the two groups,and comparing the difference of ASL cerebral blood flow around the lesion between the progressive patients and the non-progressive patients.All data were input in Excel and analyzed by SPSS24.0 statistical software.Results:1.In Qi deficiency group,1 case was shedding,3 cases in non-Qi deficiency group,33 cases in Qi deficiency group and 43 cases in non-Qi deficiency group.2.Comparisons of total cerebral blood perfusion: There was a significant difference between the cerebral blood perfusion of the affected side and that of the healthy side in 76 patients(P < 0.001);54 patients with cerebral infarction of LAA were classified as cerebral infarction of CISS,and there was a significant difference between the cerebral blood perfusion of the affected side and that of the healthy side(P < 0.001).There were 22 patients with perforator artery disease(PAD).There was no significant difference in cerebral blood flow perfusion between the affected side and the healthy side(P=0.131).3.Comparison of cerebral blood flow perfusion between Qi-deficiency group and non-Qi-deficiency group: The difference of cerebral blood flow perfusion between Qi-deficiency group and non-Qi-deficiency group(sick side cerebral blood flow perfusion-healthy side cerebral blood flow perfusion)was very significant(P < 0.001).4.Comparison of the relationship between Qi deficiency syndrome and disease progression: There was no significant difference between Qi deficiency group and non-Qi deficiency group(P=0.868).5.Comparison of cerebral blood flow perfusion between progressive group and non-progressive group: There was significant difference between progressive group and non-progressive group in cerebral blood flow perfusion of affected side(P=0.013);there was no significant difference between progressive group and non-progressive group in cerebral blood flow perfusion of healthy side(P=0.191).Conclusion:1.There is no significant correlation between stroke Qi deficiency syndrome and disease progression.The relationship between TCM syndromes and progressive stroke needs further study.2.The difference of cerebral blood flow perfusion in Qi-deficiency stroke patients is significantly smaller than that in non-Qi-deficiency stroke patients,indicating that the blood flow of Qi-deficiency stroke patients is poor,which provides important guidance for the treatment of Qi-deficiency stroke patients.3.ASL cerebral blood flow perfusion is of guiding significance in predicting the progress of cerebral infarction,which is worthy of clinical reference.