Multimodal Imaging Quantitative Analysis Of Geographic Atrophy In Aged-related Macular Degeneration

OBJECTIVETo compare the different characteristics of multimodal imaging of geographic atrophy(GA)in age-related macular degeneration(AMD).METHODSThe study observed 32 eyes of 27 patients with geographic atrophy secondary to age-related macular degeneration.Two trained reading-center-certified ophthalmologists,operating in masked fashion,independently graded the area of lesions of CFP,FAF and FFA and compared the sizes of them.RESULTSIntergrader agreement on the lesion area for diffferent images was excellent,with most differences less than 95% of the cases.Lesion size of three radiographic images shows: the average area of CFP(19.81mm2)< the average area of FAF(21.05 mm2)< the average area of FFA(23.10 mm2),but the differences in the area of CFP,FAF and FFA are not significant(P=0.629).CONCLUSIONSFundus autofluorescence imaging is the gold standard for the diagnosis of geographic atrophy due to a high correlation in lesions size of FAF and real diseased region.