Clinical Studies Of The Long-term Effect Of The Treatment Combined With Traditional Chinese And Western Medicine For IgA Nephropathy

Objective In order to further understand the long-term effect of the treatment combined with traditional chinese and western medicine for IgA nephropathy based on the theory of tonifying deficiency,resolving blood stasis,and dispelling wind-dampness.Methods By a single center retrospective case-control study,we obtained the clinical,laboratory examination and treatment of IgA nephropathy from the registration database in Hangzhou Hospital of TCM in 2008.Group A:treatment combined with traditional chinese and western medicine(Foundation treatment,Traditional Chinese Medicine,Glucocorticoid and/or Immune Inhibitors).Group B:Treatment only with traditional chinese medicine.We made a follow-up visit for at last 12 months from renal biopsy to assess the patients’ urine and kidney function before and after the treatment.And the end point events are defined as entering ESRD or eGFR decreased by more than 50%or Scr increased by more than 50%,and using Kaplan-Meier method to calculate the accumulation of kidney survival rate.Results 49 IgAN patients were treated with traditional Chinese medicine and 174 IgAN patients were treated with the integrated traditional Chinese and western medicine.The effective rate of Group A was 89.8%with 86.2%of Group B,and the total was 87.0%.The scores of proteinuria and hematuria in patients of both group A and group B were decreased significantly.The accumulated kidney survival rate of The 223 patients after 1,3,5,7 years were 100%,99.5%,95.7%and 91.2%respectively.Conclusion The observation of the treatment according to the different conditions based on the theory of tonifying deficiency,resolving blood stasis,and dispelling wind-dampness showed that this scheme can significantly improve the patients’ condition and the accumulated kidney survival rate after 7 years was 91.2%.