Effects Of Parental Donor In Haploidentical Hematopoietic Stem Cell Transplantation On Hematologic Malignancies

Background and ObjectiveThe haploidentical hematopoietic stem cell transplantation (HSCT) is an effective treatment of hematologic malignancies. It is very useful for increasing the successful rate of stem cell transplantation to search an appropriate donor rapidly.Observe and compare the effect of parental to offspring grafts on the treatment of the haploidentical hematopoietic stem cell transplantation in hematologic malignancies.Materials and MethodsWe retrospectively analyzed outcomes in92patients with hematologic malignancies who underwent parental haploidentical hematopoietic stem cell transplantation were divided into four groups including father-to-son transplantations(groupA), father-to-daughter transplantations (groupB), mother-to-son transplantations (group C) and mother-to-daughter transplantations (group D) in the first affiliated hospital of zhengzhou university from August,2006to June,2012. The four groups were analysed in the incidence of graft versus host disease (GVHD), recurrence rate, and2-year diseases free survival and overall survival.By using SPSS17.0to analysis, the value less than0.05was considered as significance.ResultsEngraftment was successful in a total of92patients.The severe acute GVHD and chronic GVHD and the relapse of malignant diseases were similar in the four groups (P＞0.05). Significant difference was observed in the occurrence of Ⅲ-Ⅳ aGVHD and2-year diseases free survival (DFS) and2-year overall survival rate(OS) among four groups (P<0.05). The incidence of Ⅲ-Ⅳ aGVHD in father-to-son grafts and mother-to-daughter grafts was significantly lower than in father-to-daughter grafts and mother-to-son grafts. Father-to-son grafts and mother-to-daughter grafts had a significantly higher2-year DFS and OS, as compared with father-to-daughter grafts and mother-to-son grafts.Conclusion1The parental to offspring grafts is safe and feasible.2The same gender of patients and donors have better effect than the different gender of patients and donors in parental to offspring grafts.