The Study Of Testosterone Variation And Correlation Of Testosterone Levels With Glycometabolism,Lipid Metabolism And Bone Mineral Density In Menopausal Women

Objective: To investigate the variation of total testosterone level in peri-menopausal and postmenopausal women.To explore the effects of total testosterone and the ratio of estrogen/testosterone on glucose metabolism,lipid metabolism,bone mass loss in menopause period.Methods:This cross-sectional study enrolled 603 women,aged 40-60 years old,who were admitted to the menopausal outpatient clinic of Hangzhou Women’s Hospital.They were divided into peri-menopausal group(n= 191),early postmenopausal group(n = 341)and late postmenopausal group(n = 72).Analysis of variance(ANOVA)and t-test were used to compare the difference of testosterone level between groups.Pearson correlation analysis and partial correlation analysis were used to analyze the correlation between testosterone level,E2/T ratio and glucose metabolism indexes(FINS,FPG,HOMA-IR),lipid metabolism indexes(TC,TG,HDL,LDL,TC/HDL,TG/HDL,LDL/HDL)and bone mineral density(BMD).Results:(1)The levels of FSH,E2,T and E2/T ratio between groups were significant differences(P < 0.001),but no significant differences were found in LH,BMI and weight.Testosterone levels gradually decrease with age in women between the ages of 40 and 60.(2)There were significant differences in FINS and HOMA-IR between groups,but FBG was not.Testosterone level was correlated with FBG(r=0.127,P=0.041)and HOMA-IR(0.123,P=0.048),the E2/T ratio was correlated with FBG(r=-0.151,P=0.015)and HOMA-IR(r=-0.127,P=0.041)in early postmenopausal women.And E2/T ratio was correlated with FINS(r=-0.192,P=0.022)and HOMA-IR(r=-0.190,P=0.024)in peri-menopausal women.(3)There were significant differences in TC,HDL,LDL,TC/HDL,TG/HDL and LDL/HDL levels between groups(P < 0.05),but TG was not.Testosterone level was correlated with TG(r=0.124,P=0.048),LDL(r=0.142,P=0.024)in the early postmenopausal women,and correlated with TG/HDL(r=0.267,P=0.038)in the late postmenopausal women.The ratio of E2/T was correlated with TG(r=-0.169,P=0.040),TC(r=-0.179,P=0.029),TC/HDL(r=-0.164,P=0.046)in peri-menopausal women,and correlated with LDL(r=-0.137,P=0.029),TG/HDL(r=-0.127,P=0.043),LDL/HDL(r=-0.135,P=0.031)in early postmenopausal women.(4)The BMD of lumbar vertebrae,femoral neck and total hip decreased with the menopausal status and years after menopause.Testosterone level was correlated with total hip BMD(r=0.156,P =0.025)in early postmenopausal women,and the ratio of E2/T was correlated with lumbar BMD(r=0.295,P=0.029)in peri-menopausal women.Conclusion: Testosterone level tend to decline with age,and was associated with menopausal status.The risk of glucose,lipid metabolism disorder and bone mass loss in post-menopausal women was significantly higher than that before menopause.Glucose and lipid metabolism were positively correlated with testosterone level,and negatively correlated with E2/T ratio in menopausal women.Moreover,testosterone level was positively correlated with BMD of the total hip after menopause,and E2/T ratio was positively correlated with BMD of the lumbar spine during peri-menopause.T and E2/T ratio are expected to be the predictors of glucose,lipid metabolism disorder and bone loss in menopausal women.