Characteristics Of NLR And PLR In Peripheral Blood Of Patients With Diabetic Foot Ulcer And Its Clinical Significance Of Predicting Wound Prognosis

Objective:In this paper,we analyze the characteristics of peripheral blood neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)in patients with diabetic foot ulcer(DFU),in order to explore the clinical application value of it in evaluating the prognosis of diabetic foot ulcer wound.Methods:In this study,140 patients with type 2 diabetic foot ulcers were included.The patients with type 2 diabetic foot ulcer were followed up one year after discharge.The research objects with complete wound healing of type 2 diabetic foot ulcer were divided into recovery group(83 cases),and the research objects with poor wound healing,amputation or stump ulcer formation after amputation were divided into poor prognosis group(57 cases).NLR,PLR,gender,age,smoking history,wound time,history of interventional surgery,course of diabetes,affected side,WBC,RBC,HB,fasting blood glucose,triglyceride,albumin,cholesterol,glycosylated hemoglobin and other clinical data were collected after admission.The relationship between NLR and PLR and poor prognosis of diabetic foot ulcer was analyzed by Logistic regression,ROC curve was drawn to analyze its predictive value for the prognosis of diabetic foot ulcer.Results:(1)In the peripheral blood of patients with adverse groups of diabetic foot ulcers,the levels of NLR and PLR were significantly higher than that of the recovery group,which had significant statistical differences(P<0.05).(2)Logistic regression analysis showed that NLR was a risk factor for poor prognosis of diabetic foot ulcer(OR=3.288,95%CI 1.794-6.025,P<0.05).The Receiver operating characteristic(ROC)curve analysis showed that when the cutoff value was 4.511,the sensitivity and specificity of predicting poor prognosis of diabetic foot wound were 0.860 and 0.897 respectively(AUC=0.918,95%CI0.870-0.966,P<0.05).(3)Univariate logistic regression analysis showed that PLR was a risk factor for poor prognosis of diabetic foot ulcer(OR=1.007,95%CI 1.003-1.011,P<0.05).Multivariate logistic regression analysis showed that PLR was not an independent risk factor for diabetic foot ulcer(OR=1.003,95%CI 0995-1.010,P>0.05).Conclusions:(1)There were higher levels of NLR and PLR in peripheral blood of patients with poor prognosis of diabetic foot ulcer.(2)NLR is an independent risk factor for poor prognosis in patients with diabetic foot ulcer.When NLR in peripheral blood of patients with diabetic foot ulcer is more than4.511,the risk of poor prognosis is higher.(3)PLR is a risk factor for poor prognosis in patients with diabetic foot ulcer.