| OBJECTIVE:To quantitatively evaluate the gastric emptying rate of diabetic patients by oral gastric contrast-enhanced ultrasound,analyze its related influencing factors,and explore the indicators to predict the gastric emptying rate of diabetic patients.METHODS:The whole stomach volume of 0min,30min and 60min were measured after oral contrast-enhanced ultrasonography in ultrasound department of our hospital from September 2018 to October 2020,and the gastric emptying rates of half an hour and one hour were calculated.Finally 138 cases were selected.The patients were divided into non-diabetic group and diabetic group according to whether they had diabetes or not.The differences of gastric volume and gastric emptying rate between non-diabetic group and diabetic group were analyzed.The correlation between gender,fasting blood glucose,two-hour postprandial blood glucose,glycosylated hemoglobin,course of disease,upper gastrointestinal symptoms and gastric emptying rate in diabetic group was analyzed,and multiple linear regression analysis was performed.RESULTS:1.There were 78 cases in the non-diabetic group and 60 cases in the diabetic group.There was no significant difference both in gender(χ~2=0.013,P=0.911)and age(t=-1.081,P=0.282)between the two groups.2.There was no significant difference in the history of hypertension,coronary heart disease,hyperlipidemia,smoking and drinking between the non-diabetic group and the diabetic group(P>0.05).3.The incidence of upper gastrointestinal symptoms in the diabetic group(61.67%)was higher than that in the non-diabetic group(24.35%),and the difference was statistically significant(χ~2=19.576,P=0.000).In non-diabetic group and diabetic group,the gastric emptying rate of patients with upper gastrointestinal symptoms was lower than that without upper gastrointestinal symptoms(P<0.05).Among the patients without upper gastrointestinal symptoms,the gastric emptying rate in the diabetic group(22.16±10.33%,45.51±10.76%)was lower than that in the non-diabetic group(27.89±6.26%,57.52±8.50%),and the difference was statistically significant(P<0.05).4.The gastric cavity volume of 0min,30min and 60min after oral administration of enhancer in the diabetic group(437.87±56.87ml,364.65±65.62ml,274.83±65.89ml)was higher than that in the non-diabetic group(405.04±66.82ml,296.65±48.73ml,179.59±45.67ml).The half-hour gastric emptying rate and one-hour gastric emptying rate in the diabetic group(17.70±7.80%,37.37±12.04%)were lower than those in the non-diabetic group(26.37±8.08%,55.42±10.41%),and the difference was statistically significant(P<0.05).5.There was no significant difference in gastric emptying rate between different genders in non-diabetic group(all P>0.05).In diabetic group,the gastric emptying rate in female patients was significantly lower than that in male patients(P<0.05).6.According to the correlation analysis of Pearson and Spearman,there was no significant correlation between age and gastric emptying rate both in non-diabetic group and diabetic group(all P>0.05).In diabetic group,gender,fasting blood glucose,two-hour postprandial blood glucose and upper gastrointestinal symptoms were correlated with half-hour gastric emptying rate and one-hour emptying rate(all P<0.05).There was no significant correlation between glycosylated hemoglobin and the course of disease with half-hour gastric emptying rate(all P>0.05),but there was a correlation between glycosylated hemoglobin and the course of disease with one-hour gastric emptying rate(all P<0.05).7.Multiple linear stepwise regression analysis showed that fasting blood glucose and upper gastrointestinal symptoms were significant independent predictors of half-hour gastric emptying rate and one-hour gastric emptying rate in diabetic patients,and the regression coefficients were-1.653,-1.935 and-9.894,-14.788,respectively.CONCLUSION:1.Oral contrast-enhanced ultrasonography can effectively calculate the gastric emptying rate at different times of diabetic patients;the gastric volume of diabetic patients is higher than that of non-diabetic patients,and gastric emptying rate was slower in diabetic patients than non-diabetic patients.2.The gastric emptying rate of female diabetic patients was lower than that of male diabetic patients,and diabetic patients had a higher incidence of upper gastrointestinal symptoms,and some diabetic patients with delayed gastric emptying have no obvious upper gastrointestinal symptoms.3.There were correlations between gender,fasting blood glucose,two-hour postprandial blood glucose,upper gastrointestinal symptoms with half-hour gastric emptying rate and one-hour emptying rate in diabetic group.Hb A1c and the course of disease had correlation with one-hour gastric emptying rate.4.Fasting blood glucose and upper gastrointestinal symptoms are significant independent predictors of gastric emptying rate in diabetic patients.Gastric emptying rate decreases with the increase of fasting blood glucose,and the gastric emptying rate is lower in diabetic patients with upper gastrointestinal symptoms. |
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