Relationship Between Subclinical Hypothyroidism And Ischemic Stroke In Elderly Patients With Type 2 Diabetes Mellitus

Objective: To explore the relationship between subclinical hypothyroidism and ischemic stroke.Method: 114 patients with type 2 diabetes in the Fifth Affiliated Hospital of new medical university from December 2019 to December 2020 were collected and divided into stroke group(55 cases)and non stroke group(59 cases)according to the occurrence of ischemic stroke.Height and weight were measured,and body mass index(BMI),thyroid stimulating hormone(TSH),triglyceride(TG),total cholesterol(TC)and high density lipoprotein(HDL)were calculated(HDL,LDL,bun,Cr and FPG were analyzed.Result:(1)there was no significant difference in age,gender,history of coronary heart disease and hypertension between the two groups(P > 0.05),that is,there was no difference in the distribution of age,gender,history of coronary heart disease and hypertension between the two groups;there was significant difference in BMI and smoking history between the two groups(P < 0.05)(2)there was no significant difference in FT4,creatinine and urea nitrogen between the two groups(P > 0.05),but there were significant differences in blood glucose,TG,TC,HDL,LDL,TSH and FT3 between the two groups(P < 0.05).Compared with the non stroke group,the levels of TG,LDL,TSH in the stroke group were significantly higher,while the levels of HDL were lower;(3)the EF of the two groups was significantly higher(4)in the two groups,TSH was positively correlated with TG,blood glucose and FT3,with statistical significance;the other indicators were not statistically significant;(5)Binary logistic regression analysis showed that after controlling for age,BMI and other confounding factors,TSH may be an independent risk factor for ischemic stroke,and HDL is an independent protective factor for ischemic stroke.Conclusions: subclinical hypothyroidism may be an independent risk factor for ischemic stroke.