The Value Of FibroScan And APRI In The Diagnosis Of Hepatitis B Cirrhosis

Objective The correlation between FibroScan,APRI and the degree of liver lesions was discussed.The value of these two indexes in the differential diagnosis of chronic hepatitis B and hepatitis B cirrhosis,compensated and decompensated hepatitis B cirrhosis was further evaluated.MethodsThere are 160 patients with hepatitis B virus as the patient group,including 80 patients with chronic hepatitis B and 80 patients with hepatitis B cirrhosis.At the same time,60 cases of healthy subjects were chosen as the normal control group.Blood routine and biochemical indicators were detected.The APRI model was consisted of Aspartate aminotransferase(AST)and platelet(PLT),calculating formula for APRI index =(AST/upper limit of normal)*100/PLT.Analyze the liver stiffness measurement detected by the liver instantaneous elastography(FibroScan).Spearman analysis method was used to analyze the correlation between FibroScan,APRI and the degree of hepatitis B liver cirrhosis;binary logistic regression was used to establish regression models for FibroScan and APRI.The area under the ROC curve was used to evaluate the efficacy of the above two indicators and the regression model for the differential diagnosis of chronic hepatitis B and hepatitis B cirrhosis,compensated and decompensated hepatitis B cirrhosis.Results1.As chronic liver disease progresses,from the normal group,to the chronic hepatitis B group,and then to the hepatitis B cirrhosis group,the APRI value shows an upward trend,and there are significant differences between the three groups(P<0.001).FibroScan in the hepatitis B cirrhosis group was significantly higher than that in the chronic hepatitis B group,the difference was statistically significant(P<0.001).FibroScan,APRI had significant differences in different stages and grades of hepatitis B cirrhosis(P<0.05).2.It is a positive correlation between FibroScan,APRI and the degree of hepatitis B cirrhosis,and the correlation coefficients rs are 0.488 and 0.493(P<0.001).3.0.885 and 0.860 are respectively the area under the ROC curve of FibroScan and APRI in the differential diagnosis of chronic hepatitis B and hepatitis B cirrhosis.When FibroScan combined with APRI differentially diagnosed chronic hepatitis B and hepatitis B cirrhosis,the area under the ROC curve was 0.905.FibroScan,APRI differential diagnosis of compensatory and decompensated liver cirrhosis ROC area under the curve are 0.786,0.789.When FibroScan combined with APRI diagnoses the compensatory and decompensated liver cirrhosis,the area under the ROC curve is0.843,which is significantly higher than Fibroscan,APRI alone in the differential diagnosis of chronic hepatitis B and hepatitis B cirrhosis,compensatory and decompensated hepatitis B cirrhosis.Conclusions1.We believe that FibroScan,APRI and hepatitis B liver cirrhosis are positively correlated,both of which can reflect the severity of hepatitis B cirrhosis.2.The combination of FibroScan and APRI can contribute to differentially diagnose chronic hepatitis B and hepatitis B cirrhosis,compensated and decompensated hepatitis B cirrhosis,which can improve the diagnosis rate,but also reduce the missed diagnosis rate.