Analysis Of Metabolic Changes In Patients With Primary Aldosteronism And The Correlation With Age And Gender

Objectives To analyze primary aldosteronism(primary aldosteronism,PA,hereinafter referred to as the original aldehyde disease)patients and Essential hypertension(essential hypertension,EH)patients with the metabolic change the situation and the analysis of the gender,age,to understand the correlation between the original aldehyde disease patients and Essential hypertension patients for the change of biochemical indexes and vitamin D levels.The aim of this article is to reduce the incidence of target organ damage,improve the quality of life of patients with primary aldosteronism,and provide a basis for the diagnosis and treatment of hypertension.Methods Retrospective data analysis was used in this research.A total of 91 patients with PA diagnosed in Tangshan Workers’ Hospital from January 2017 to August 2020were selected as the PA group,at the same time 112 patients diagnosed with essential hypertension(EH)during the same period were included as the EH group.Medical history collection,physical examination,laboratory examination and related special examinations were required for patients in both groups to ensure the completeness of case data.The disorder degree of metabolic indexes such as blood glucose,ions,blood lipids,uric acid,serum creatinine and the incidence rate of metabolic syndrome(MS)in 2 groups were compared with the differences of gender and age.Results 1 Between the two groups of course of the disease,age,height,weight,BMI,fasting blood glucose(GLU),cholesterol(CHOL),triglyceride(TG),high-density lipoprotein cholesterol(HDL),low density lipoprotein(LDL)cholesterol,homocysteine(CYS),serum creatinine(SCR),uric acid(UA),vitamin D(Vit D)and the level of plasma aldosterone concentration(PAC),there were no statistically significant difference among them(P>0.05).However,there were statistically significant differences in waist circumference,systolic blood pressure(SBP)and diastolic blood pressure(DBP),serum potassium level,direct renin concentration(DR)and plasma aldosterone/renin(ARR)(P<0.05).2 There were no statistically significant differences in course of disease,age,BMI,SBP,DBP,serum potassium,GLU,TG,CHOL,HDL,LDL,Cys,Vit D and PAC levels between male and female patients in PA group(P>0.05),but there were statistically significant differences in height,weight,waist circumference,SCR,UA,DR and ARR(P<0.05).3 There were no statistically significant differences in mean course of disease,DBP,serum potassium,Glu,CHOL,HDL,LDL,Cys,Vit D and PAC levels between male and female patients in EH group(P>0.05),yet there were statistically significant differences in age,height,weight,waist circumference,BMI,SBP,TG,SCR,UA,DR and ARR(P<0.05).4 Compared with the EH group,the detection rate of metabolic syndrome(MS)and its abnormal components(TG,HDL,static blood pressure,GLU)in PA group had no statistically significance(P>0.05).The number of cases of abdominal obesity was less than that in the EH group,and the difference was statistically significant(P<0.05).5 In the PA group,there was no statistically significance in the detection rate of MS and its abnormal components(abdominal obesity,TG,HDL,blood pressure,GLU)in male patients compared with female patients(P>0.05).6 In the EH group,there was no statistically significant difference in the detection rate of MS and its abnormal components(abdominal obesity,TG,HDL,blood pressure and GLU)between male patients and female patients.7 In the PA group,for male patients,comparing age>55years with age≤55 for the detection rate of MS and the components of metabolic syndrome(abdominal obesity cases and average GLU,TG,HDL,blood pressure),there was no statistically significant difference(P>0.05).AS for female patients,comparing age>55 with age≤55 for the detection rate of MS and the components of metabolic syndrome(abdominal obesity and GLU,TG,HDL,blood pressure)detection rate,there was no statistically significant difference(P>0.05).8 In the EH group,for male patients,comparing age>55 years with age≤55 for the detection rate of MS and the components of metabolic syndrome(abdominal obesity cases and average GLU,TG,HDL,blood pressure),there was no statistically significant difference(P>0.05).AS for female patients,comparing age>55 with age≤55 for the detection rate of MS and the components of metabolic syndrome(abdominal obesity and GLU,TG,HDL,blood pressure)detection rate,there was no statistically significant difference(P>0.05).Conclusions 1 In patients with both PHA and essential hypertension,abdominal obesity and metabolic syndrome are more likely to occur in males than females,and the prevalence of metabolic syndrome is higher in males older than 55 years than in females.2 Compared with patients with essential hypertension,the blood pressure level of patients with PHA was higher,and the detection rate of abdominal obesity in PHA patients was higher than that in patients with essential hypertension.Figure 0;Table 14;Reference 108...