| Objectives Cortistatin(CST)is a recently discovered cyclic neuropeptide with a variety of biologically active effects,named for its ability to inhibit cortical activity.CST can be widely expressed in the nervous system,endocrine system and immune system.Studies have shown that it is associated with insulin resistance,insulin secretion and chronic inflammation,and plays an important role in the development of type 2 diabetes mellitus(T2DM),atherosclerosis and metabolic syndrome.Patients with T2 DM are often accompanied by Non-alcoholic fatty liver disease(NAFLD).Insulin resistance is a common pathological mechanism between NAFLD and T2 DM.The purpose of this study is to assess the relationship between serum CST levels and NAFLD in T2 DM.Methods In the current study,we selected 90 with T2 DM patients(56 with NAFLD patients and 34 without NAFLD patients)admitted to Hebei General Hospital between March 2019 and November 2019 as a DM group,and 83 patients non-diabetes(39 with NAFLD patients and 44 without NAFLD patients)who were examined during the same period as a non-DM group.The basic information,past medical history and diabetes of duration were collected.Body mass index(BMI)was calculated.Glucose metabolismrelated indicators including fasting plasma glucose(FPG),fasting insulin(FINS)and fasting c-peptide were recorded.The biochemical indexes,including liver function,blood lipid and Serum uric acid,were recorded.Insulin Resistance Index(HOMA-IR)and Insulin Cell Function Index(HOMA-β)were calculated for each individual.Serum CST and CRP were measured by ELISA method.The quantitative analysis of fatty liver ultrasound images were performed.We recorded all data into an Excel table,and used SPSS22.0 software to perform statistical analysis of the data.Results 1 The basic index in different groups: The age of each group was no significant difference(P>0.05).The BMI level is significantly lower in two groups of simple DM group and NC group than in DM+NAFLD,and the BMI of simple NAFLD group is higher than that of NC group,which differences are statistically significant(P<0.05).The diastolic pressure level is significantly higher in two groups of DM+NAFLD and simple NAFLD than in NC group(P<0.05).There are statistical differences in gender composition in different groups(P<0.05).2 Liver function in different groups: The DBIL is significantly higher in two groups of DM+NAFLD and simple DM group than in NC group(P<0.05).The serum DBIL level is significantly up-regulated in the DM+NAFLD group compared to the simple NAFLD group(P<0.05).Serum ALT level in DM+NAFLD group and simple NAFLD group is higher than those in simple DM group and NC group,and serum AST level in DM+NAFLD group and simple NAFLD group is higher than those in simple DM group(P<0.05).3 Blood lipids,uric acid and inflammation indicators in different groups: The LDL-C of DM+NAFLD group and simple DM group was higher than that of simple NAFLD group and NC group(P<0.05),TC and HDL-C were lower than that of simple NAFLD group and NC group(P<0.05).The levels of TG in simple DM group and NC group were significantly lower than those in DM+NAFLD group,simple NAFLD group(P<0.05).Apo B in DM+NAFLD group and simple DM group is lower than that in simple DAFLD group(P<0.05).Uric acid in DM+NAFLD group and simple NAFLD group was higher than that in NC group(P<0.05).Compared with simple NAFLD group and NC group,the CRP levels in DM+NAFLD group and simple DM group are significantly higher(P<0.05).4 Islet functions in different groups: Compared with NAFLD group and NC group,FPG in DM+NAFLD group and simple DM group is higher(P<0.05).FINS in DM+NAFLD group,simple DM group and NC group is significantly lower than that in simple NAFLD group,and C-peptide in simple DM group and NC group is lower than that in simple NAFLD group(P<0.05).HOMA-IR in DM+NAFLD group and simple NAFLD group is lower than that in NC group,and HOMA-β in simple NAFLD group and NC group is significantly higher than that in simple DM group(P < 0.05).5 Serum CST in different groups: The levels of CST in DM+NAFLD and simple DM group are significantly lower than that in NC group,and CST levels in simple DM group are significantly lower than that in simple NAFLD group(P<0.05),However,in the diabetic group,with or without NAFLD,CST is no statistical difference.Similarly,in the non-diabetic group,with or without NAFLD,CST also is no statistical difference(P>0.05).6 Using the correlation analysis shows the serum CST level is negatively correlated with TC,LDL-C,FGB,HOMA-IR and HOMA-β,While it has positively correlated with HDL-C.The result of regression analysis shows that LDL-C and HOMA-β are the independent factor influencing serum CST.Conclusion 1 The level of serum CST in diabetic patients was significantly lower than that in non-diabetic patients,and CST is correlated with T2 DM,indicating that CST may play a mediating role in the occurrence and development of T2 DM.2 There is no correlation between CST and NAFLD.The specific mechanism needs to be further studied.Figure 3;Table 8;References 139... |
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