Cross-sectional Study On The Relationship Between Total Cruciferous Vegetables And Isothiocyanate Intake And Metabolic Syndrome

Objective: To understand the prevalence of Metabolic Syndrome(Mets)among adults in Northeast China and explore the relationship between the intake of total cruciferous vegetables(CV)and isothiocyanates(ITCs)and Mets,to provide a scientific basis for the prevention and control of Mets.Methods: Using cross-sectional data from a natural population cohort in the Northeast region,a total of 15510 people were subjected to physical examinations and biochemical tests from September 2018 to December 2019.The dietary intake was obtained according to the food frequency questionnaire.The revised version of the National Cholesterol Education Program Adult Group reported the third diagnostic criteria as the diagnostic criteria for Mets.SAS9.4 software was used for statistical analysis.t test and chi-square test were used to analyze the differences in baseline characteristics between Mets and nonMets groups.Pearson correlation analysis method was used to analyze the correlation between general diet and nutrients,total CV and ITCs.Factor analysis was used to construct dietary patterns.Univariate and multivariate logistic regression models were used to analyze the association between total CV and ITCs intake and Mets.Results: A total of 14615 subjects were included and their average age is(51.62±10.95)years old.In the whole population,the prevalence of Mets was 34.68%.The prevalence rates of males and females were 33.82% and 35.10%,respectively.After adjusting for potential confounding factors,it was found that the fourth quintile of total CV intake compared with the first quintile(Q1),the odds ratio(OR)value(95% Confidence interval,CI)of Mets was 0.86(0.75-0.98),and the trend test was statistically significant(P=0.015).When the intake of total CV and ITCs increased by one standard deviation(Standard Deviation,SD),the ORs(95% CI)of Mets were 0.92(0.87-0.97)and 0.94(0.89-0.99),respectively.In a stratified analysis,when the total CV intake of men and women increased by one SD,the ORs(95% CI)of Mets were 0.91(0.83-0.99)and 0.93(0.87-0.99),respectively.In population with BMI<25,the Q4 of total CV intake compared with the Q1,the Mets OR(95% CI)was 0.73(0.59-0.91),and the trend test was statistically significant(P=0.006);When the total CV intake of people with BMI<25 and BMI≥25 increased by one SD,the ORs(95% CI)of Mets were 0.89(0.82-0.97)and 0.94(0.88-1.00),respectively.In the Han population,when the amount of total CV intake increased by one SD,the OR(95% CI)of Mets was 0.90(0.84-0.97);the Q4 of ITCs intake compared with the Q1,the OR(95% CI)of Mets was 0.82,(0.69-0.99);when the amount of ITCs intake increased by one SD,the OR(95% CI)of Mets was 0.91(0.85-0.98),and no obvious interaction was found.In the combination of obesity+hypertension+TG increasement and obesity+TG increasement+HDL-C reduction,when the amount of total CV intake increased by one SD,the ORs(95% CI)of Mets were 0.94(0.88-1.00)and 0.92(0.86-0.99),respectively.Conclusion: Adequate intake of total CV and ITCs is negatively associated with the prevalence of Mets,and this effect is mainly manifested in the Han population.In Mongolian and other ethnic population,no statistically significant association has been observed between total CV and ITCs intake and Mets prevalence,and further exploration and demonstration are needed in the future.