Associations Of Uric Acid With Metabolic Syndrome In Chronic Disease Patients With Overweight And Obesity In General Practice

Objective:Previous studies have shown that body mass index(BMI)or serum uric acid(UA)is closely related to metabolic syndrome(Mets),but the significance of BMI combined with UA in the assessment of Mets and its components is unknown..The main purpose of this study is to investigate the effects of BMI,UA alone or a combination of the two factors in the assessment of Mets.Method:A cross-sectional study was conducted on 608 overweight and obese patients(275 males,333 females)aged≥35 years who were treated in the general practice ward of the First Affiliated Hospital of China Medical University from January 2019 to April2020.Subjects were divided into hyperuricemia group and non-hyperuricemia group according to UA level.The non-hyperuricemia group was divided into three levels(33.33 th and 66.66 th percentiles as cutoff points).Then,two levels of BMI and four levels of UA were combined into groups.Logistic regression was used to evaluate the incidence of metabolic syndrome and its components by single factors and their combination.Result : Multivariate Logistic regression showed that compared with overweight,obesity was an independent risk factor for metabolic syndrome,hypertension,hyperglycemia,and low HDL cholesterolemia(adjusted odds ratio [ORA] is 1.54-2.45,all P < 0.05).Also adjust the confounding factors,compared with the low level of uric acid(Non-hyperuricemia in < 33.33 th percentile),hyperuricemia(UA>420umol/L)is the metabolic syndrome,hypertension,high blood triglycerides,low HDL cholesterol independent risk factors(adjusted odds ratio(ORA)is 1.74-3.71,all P < 0.05).Obesity and upper stratum of non-hyperuricemia(>66.66 th percentile in non-hyperuricemia)had a combined effect on metabolic syndrome and hypertension(adjusted odds ratio [ORA]from 3.07 to 4.70,all P < 0.05).Conclusion: The composition of metabolic syndrome in patients with chronic diseases combined with overweight or obesity in general practice services is relatively high,BMI and UA were correlated with metabolic syndrome,and there was a combined effect of BMI and UA in Mets,and the combination of the two had a better value than single factor evaluation of Mets.BMI and UA have a combined effect in Mets,and the combined effect of the two has a better value than single factor assessment of Mets.In order to help general practitioners better manage overweight and obese people in clinical work,this study suggests strengthening uric acid monitoring in obese patients with normal uric acid levels and early intervention if necessary.