Association Between Dietary Glycemic Index And Glycemic Load And Hyperuricemia-a Cross-sectional Study

Objective: Hyperuricemia(HUA)is a condition with abnormal blood uric acid concentration,and the prevalence of HUA in China is on the rise.Some epidemiological studies have reported the associations between common food groups and HUA,however,there is still a lack of studies assessing the association between dietary glycemic index(GI)and glycemic load(GL)and HUA.The aim of this study was to investigate the aforementioned association through a large cross-sectional study.Methods: This study was based on the Northeast China Biobank,and all participants enrolled between September 2018 and December 2019 were selected as the study population.Patients with HUA were determined by blood uric acid concentration(>420μmol/L for male,>360μmol/L for female).The subjects’ demographic characteristics,frequency of food intake,and disease history were investigated using questionnaires.We calculated the daily carbohydrate intakes of the study subjects by using a semi-quantitative food frequency questionnaire containing 110 items,and calculated the dietary GI and GL values based on the food glycemic index table provided in the China Food Composition Tables(Sixed Edition).The t-test or chi-square test was used to analyze the differences in general characteristics between HUA and non-HUA groups.Logistic regression model was used to evaluate the association between dietary GI and GL and HUA,and the association between dietary GI and GL and HUA was further assessed by several stratification analyses.Results: A total of 14529 subjects were included in this study,of which 2283 were diagnosed with HUA,with a prevalence rate of 15.7%.Except for physical activity and the presence or absence of heart disease,the distributions of the other exposures or characteristics were statistically different between HUA and non-HUA groups.After adjusting for age,gender,race,body mass index,education level,family income,smoking/drinking status,the presence or absence of chronic diseases,total energy,total dietary fiber,protein,fat and carbohydrate intakes,logistic regression analysis revealed that compared with the lowest dietary GI and GL groups,the odds ratios(95% confidence intervals)of the highest dietary GI and GL groups were 0.86(0.70,1.06)and 0.79(0.60,1.05),respectively.The results of subgroup analyses showed that the association between dietary GI and GL and the prevalence of HUA was still not statistically significant.Conclusion: Our study did not find a statistical association between dietary GI and GL and HUA.Considering the limitations of cross-sectional studies,the results of our study still need to be further verified by higher quality cohort studies and randomized controlled trials.