| Objective: The selection of liver grafts is crucial for the success of transplantation.Liver fibrosis and hepatic steatosis are associated with an increased risk of graft loss.The aim of this study was to evaluate the ability of transient elastography(TE)in liver grafts from brain-dead donors(DBD).Methods: Analyze 40 cases of brain-dead donors during May 2019 to December 2020.TE and blood samples were tested before liver transplantation and a biopsy was performed in operation.The diagnostic accuracy of the TE values were compared with that of pathology results.The latter is a gold standard for evaluating liver grafts.The donors enrolled were grouped by fibrosis stage and steatosis degree according to Kleiner’s scoring system respectively.SPSS 22.0 statistical software was used to analyze the evaluation of transient elastography on the quality of donor liver.Results: The values of liver stiffness(LS)in different fibrosis groups were 8.73±1.98 k Pa for F0,9.66±3.33 k Pa for F1 and 13.90±3.80 k Pa for F2.Differences were statistically significant(P=0.002).Tukey test showed that different between F2&F0 or F2&F1 was statistically significant(P<0.001).There was no statistically significant difference between F1 and F2.The value of LS had a positive correlation with fibrosis stage(r=0.561,P < 0.001).The area under receiver operating characteristic curve(AUROC)was 0.871 for F2 stage fibrosis and cut-off value was 10.65 k Pa.Controlled attenuation parameter(CAP)in different steatosis groups were 229.78±16.34 d B/m for S0,258.56±26.81 d B/m for S1 and 286.44 ± 31.56 d B/m for S2.Significant differences existed among those groups(P<0.001).CAP was correlated with steatosis degree(r=0.692,P<0.001).The AUROC for S1 and S2 stage were 0.878 and 0.900,cut-off values were 248.5d B/m and 278 d B/m respectively.Conclusions: Transient elastography values could indicate liver fibrosis and hepatic steatosis from brain-dead donors objectively with a high diagnostic accuracy. |
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