| Objective: 1.To compare the blood biochemistry and body morphology of overweight/obese type 2 diabetes patients before and after glucagon-like peptide-1 receptor agonist treatment,and evaluate the efficacy of GLP-1RA in the treatment of overweight/obese T2 DM patients.2.Compare the baseline indicators of the BMI drop ≥5.0% group and the BMI drop <5.0% group to explore the factors that may affect the weight loss effect of GLP-1RA on overweight/obese T2 DM patients.Methods: A total of 65 overweight/obese T2 DM patients who were treated in Cangzhou Central Hospital from January 2020 to August 2020 were selected.The clinical data were complete and they were willing to cooperate with the study.All patients were treated with GLP-1RA liraglutide for 26 weeks on the basis of the original treatment,and the changes in blood biochemistry and body morphology were compared before and after treatment.According to whether the BMI has fallen by more than 5.0% from the initial level,the study sample is divided into two subgroups.Those with a decrease of ≥5.0% in BMI were classified as group A;those with a decrease of less than 5.0% in BMI were classified as group B;the baseline indicators of the two subgroups A and B were compared.Use correct statistical methods to process the data.Results:1.Efficacy evaluation of GLP-1RA:1)Compared with before treatment,after 26 weeks of liraglutide treatment,fasting blood glucose,2 hours postprandial blood glucose,and glycosylated hemoglobin were significantly reduced,the difference was statistically significant(P<0.05);after 26 weeks of treatment,the insulin resistance index decreased compared with the previous,Pancreatic β-cell function index increased compared with the previous,the difference was statistically significant(P<0.05);after 26 weeks of treatment,triglycerides,total cholesterol,and low-density lipoprotein cholesterol decreased compared with the previous,the difference was statistically significant(P<0.05),high-density lipoprotein cholesterol was slightly higher than before,but there was no statistical difference before and after treatment(P>0.05);after 26 weeks of treatment,the average arterial pressure decreased by(2.69±2.8)mm Hg,the difference was statistically significant(P<0.05).2)After 26 weeks of liraglutide treatment,BMI was significantly lower than before,and the difference was statistically significant(P<0.05).Compared with before treatment,the area of visceral fat was significantly reduced after liraglutide treatment,the difference was statistically significant(P<0.05),and the area of subcutaneous fat was reduced compared to before treatment,but there was no significant difference(P>0.05).3)After 26 weeks of liraglutide treatment,the thickness of the carotid artery intima-media decreased,and the difference was statistically significant(P<0.05).2.Discussion on the factors affecting the weight loss effect of GLP-1RA:A total of 60 participants were included in this study,including 17 women and 43 men.Among the 60 participants,there were 32 cases(53.3%)in group A,including 13 women and 19 men;and 28 cases(46.7%)in group B,including 4 women and 24 men.76.5% of female patients had a BMI decrease of ≥5.0%,and 44.2% of male patients had a BMI decrease of ≥5.0%.The comparison of gender,initial BMI,VFA,hunger,and eating behavior types between the two groups showed statistical differences(P<0.05);while the two groups had no statistically significant differences in age,FPG,Hb A1 c,SFA,appetite,and satiety Difference(P>0.05).The results of univariate regression analysis showed that the differences in gender,initial BMI,VFA,hunger,and dietary behavior types were statistically significant(P<0.05).Conclusion:1.GLP-1RA can effectively reduce FPG,2h PBG and Hb A1 c in overweight/obese T2 DM patients,restore pancreatic β-cell function,improve insulin resistance,reduce weight,reduce VFA,reduce carotid artery intima-media thickness,and affect blood pressure,TG,TC,LDL-C also has a certain improvement effect.2.The higher the initial BMI,the larger the VFA,and female patients have the better weight loss effect of GLP-1RA;hunger and the type of eating behavior will affect the weight loss effect of GLP-1RA.The stronger the hunger,the worse the weight loss effect.Patients with restricted eating behavior types have significant weight loss effects. |
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