Study On The Value Of Coagulation Function Related Indexes In The Bite Of Trimeresurus Stejnegeri

Objective: To analyzed the clinical data of the patients with Trimeresurus stejnegeri snake bite retrospectively analyzed,summarized its dynamic change characteristics of coagulation function index,discuss the related parameters of blood coagulation function and disease severity,treatment intensity(antivenoms dosage,the number of times,the use of adjuvant therapies dose,frequency),the length of time,the correlation of treatment costs.Table 2-3 Comparison of abnormal time and peak time.Methods:1.The abnormal rate of Fibrinogen Degradation Products(FDP)was the highest(81.48%),among which the abnormal rate of Fibrinogen Degradation Products(FDP)was the highest(81.48%).The abnormal rate of platelet was the lowest(8.64%).2.There was a positive correlation between FDP and platelet dose.International Normalized Ratio of PT and prothrombin was Normalized Ratio.INR),Activated Partial Thromboplastin Time(APTT),Thrombin Time(TT)and FDP were positively correlated with the dosage of cryoprecipitates.FIB was negatively correlated with the dosage of cryoprecipitate,TT and FDP were positively correlated with the treatment cost,and FIB was negatively correlated with the treatment cost,with statistical significance(P < 0.05).3.After local wound invasive treatment before hospital,8 cases(66.67%)of the 12 patients with Trimeresurus stejnegeri snake bite had more than local wound blood flow,which was significantly higher than that of the patients without invasive treatment,and 9 cases(75%)needed to reuse cryoprecipitate.The prolongation time of PT and TT in patients undergoing wound incision or local debridement was greater than 5s,with statistical significance(P < 0.05).4.The median time when FDP began to appear abnormal was 7.50 h,and reached the peak earlier,and the median time when FDP reached the peak was 11.50 h.The abnormal start time of TT was the latest and reached the peak at the latest.The median start time of abnormal was11.50 h and the median peak time was 46.50 h.The difference was statistically significant(P < 0.05).5.The median level of Pt,INR,TT and Fib from the first day to the fourth day showed a decreasing trend on the first and second days,and increased slightly on the third day compared with the second day,but gradually decreased on the fourth day.APTT gradually decreased to normal,while FDP showed a trend of gradual decline,but all of them were higher than normal within four days.6.It was found in this retrospective study that the treatment of Trimeresurus stejnegeri snake bite was still based on the addition of cryoprecipitate(78.75%),followed by the addition of antivenom(31.58%).Results:1.The abnormal rate of Fibrinogen Degradation Products(FDP)was the highest(81.48%),among which the abnormal rate of Fibrinogen Degradation Products(FDP)was the highest(81.48%).The abnormal rate of platelet was the lowest(8.64%).2.There was a positive correlation between FDP and platelet dose.International Normalized Ratio of PT and prothrombin was Normalized Ratio.INR),Activated Partial Thromboplastin Time(APTT),Thrombin Time(TT)and FDP were positively correlated with the dosage of cryoprecipitates.FIB was negatively correlated with the dosage of cryoprecipitate,APTT、TT and FDP were positively correlated with the treatment cost,and FIB was negatively correlated with the treatment cost,with statistical significance(P < 0.05).3.After local wound invasive treatment before hospital,8 cases(66.67%)of the 12 patients with Trimeresurus stejnegeri snake bite had more than local wound blood flow,which was significantly higher than that of the patients without invasive treatment,and 9 cases(75%)needed to reuse cryoprecipitate.The prolongation time of PT and TT in patients undergoing wound incision or local debridement was greater than 5s,with statistical significance(P < 0.05).4.The median time when FDP began to appear abnormal was 7.50 h,and reached the peak earlier,and the median time when FDP reached the peak was 11.50 h.The abnormal start time of TT was the latest and reached the peak at the latest.The median start time of abnormal was 11.50 h and the median peak time was 46.50 h.The difference was statistically significant(P < 0.05).5.The median level of Pt,INRand TT from the first day to the fourth day showed a decreasing trend on the first and second days,and increased slightly on the third day compared with the second day,but gradually decreased on the fourth day.FIB showed a trend of gradually decreasing from the first day to the third day,and increasing from the fourth day.APTT gradually decreased to normal,while FDP showed a trend of gradual decline,but all of them were higher than normal within four days.6.It was found in this retrospective study that the treatment of Trimeresurus stejnegeri snake bite was still based on the addition of cryoprecipitate(78.75%),followed by the addition of antivenom(31.58%).Conclusion:1.Local wound invasive treatment after Trimeresurus stejnegeri snake may aggravate coagulation dysfunction.Therefore,local wound invasive treatment for Trimeresurus stejnegeri snake bite patients is not recommended.2.In the early stage of the bite,FDP can be used as an ideal early warning index.3.In the evaluation of treatment process and treatment end point of patients with Trimeresurus stejnegeri snake bite,FDP was better than other coagulation function indexes.