Clinical Observation Of Tiangui Tang Combined With Estrogen And Progesterone Sequential Method In The Treatment Of Diminished Ovarian Reserve

Objective: This thesis studies the clinical performance of patients with decreased ovarian reserve function by providing Tiangui Tang combined with estrogen and progesterone sequential method and barely estrogen and progesterone sequential method separately.And then observe the changes in their AMH,FSH,E2 values,TCM symptom scores and menstrual and recurrence condition to verify the effectiveness of Tiangui Tang.The clinical efficacy provides a scientific basis for the treatment of decreased ovarian reserve by traditional Chinese medicine.Methods: Based on the principle of randomized control,66 patients met the inclusion criteria with decreased ovarian reserve function were divided into treatment group(n = 33)and control group(n = 33).The treatment group was provided with Tiangui Tang combined with estradiol valerate and dydrogesterone,and the control group was only provided with estradiol valerate and dydrogesterone.One menstrual cycle was used as a course of treatment for both groups,and the total treatment duration was 3 courses.The improvement of menstruation condition,AMH value,FSH value,E2 value,TCM symptom score and evaluation of disease efficacy were compared before and after treatment.At 3 months after the end of treatment,subjects were revisited for menstrual improvement to understand the recurrence situation of patients within 3 months.Result:1.In terms of the improvement of menstrual condition in the late menstrual period of two groups: after treatment,intra-group and inter-group comparisons both showed significant improvements(P < 0.05).2.In terms of comparison of TCM syndrome scores between two groups:after treatment,the comparison in the treatment group was P < 0.05,the control group was P > 0.05,and the total score was P<0.05;After treatment,the secondary score and total score were both P < 0.05,the difference was significant.3.In terms of improving serum hormone levels in two groups: intra-group comparison after treatment between two groups was P < 0.05;After treatment,P > 0.05,which did not show a significant difference.4.In terms of the recurrence rate in two groups: the treatment group was18.75%,the control group was 45.16%,P < 0.05,the difference was significant.Conclusion:1.Tiangui Tang combined with estrogen and progesterone sequential method can adjust the menstrual cycle of patients with decreased ovarian reserve function,improve TCM syndrome scores and improve the quality of life of patients.2.Tiangui Tang combined with estrogen and progesterone sequential method can increase serum AMH level,reduce excessive FSH and E2 levels,and improve ovarian reserve function in patients with decreased ovarian reserve function.3.Tiangui Tang combined with estrogen and progesterone sequential method can provide better long-term outcomes.