| Risk of implant failure has increased profoundly in patients with preexisting conditions(e.g.,diabetes).Current therapies adopt a one-sided focus on direct antibacterial properties of biomaterials and osteogenesis stimulation.However,in this study we demonstrated that a “chain armor”structure(Ce-TA)that mainly targets the regulation of local pathological microenvironment,providing a novel solution to scavenge reactive oxygen species(ROS)by simulating superoxide dismutase and catalase and significantly improving osteointegration under diabetic conditions.We have successfully constructed Ce-TA based on metal phenolic network biological functional interface.Therefore,Ce-TA,an ultrathin armor structure,is biocompatible and facile.Through in vitro assays we have demonstrated that Ce-TA reshaped the diabetic microenvironment into a regeneration one in a microenvironment-responsive manner,where Ce-TA regulated hypoxiainducible factor 1α(HIF-1α)activity by reducing the level of mitochondrial ROS,and effectively alleviated mitochondrial dysfunction and reprogrammed macrophage to a pro-healing state.Furthermore,we confirmed that Ce-TA showed excellent therapeutic effects on the reducing postoperative infection and enhanced osteointegration of intra-osseous implants in diabetic rat models.Our proposed strategy opens up a promising avenue of repurposing metals with intrinsic enzyme-like activity for the goal of enhancing the osteointegration in devices with orthopedic and dental applications among diabetic patients and promising future clinical transformation to increase implant success in patients with diabetes. |
PDF Full Text Request