Clinical Analysis Of 63 Interstitial Lung Disease Patients With Positive Myositis Autoantibodies

Objective: To evaluate the significance of myositis autoantibody detection in the diagnosis of interstitial lung disease(ILD),and to explore the diagnosis and treatment of ILD with the help of clinical manifestations combined with antibody results.Methods: 63 patients of ILD accurately diagnosed with the help of myositis autoantibody detection were collected retrospectively and divided into three groups: ASS-ILD group(anti-synthetase syndrome associated interstitial lung disease group,n=22),PM/DM-ILD group(polymyositis/dermatomyositis associated interstitial lung disease group,n=18)and IPAF group(interstitial pneumonia with autoimmune features group,n=23).Their clinical characteristics,treatment and prognosis were analyzed and compared.Results: The positive rates of Raynaud’s phenomenon,joint symptoms,mechanic’s hand and anti-ARS antibodies in ASS-ILD group were higher than those in IPAF group(P<0.0167).Compared with PM/DM-ILD group,ASS-ILD group had higher positive rates of Raynaud’s phenomenon,cough,dyspnea,respiratory system symptoms as the first manifestation,anti-ARS antibodies but lower positive rates of fever,muscle symptoms,skin/muscle symptoms as the first manifestation(P<0.0167).Compared with IPAF group,PM/DM-ILD group had higher positive rates of muscle symptoms,skin symptoms,skin/muscle symptoms as the first manifestation,anti-ARS antibodies and anti-MDA5 antibody but lower positive rates of respiratory system symptoms as the first manifestation(P<0.0167).In this study,chest radiological findings of all patients were mainly NSIP.The abnormality in pulmonary functions manifested mainly as diffusion dysfunction and restrictive ventilatory dysfunction.87.3% of all patients were treated with glucocorticoid combined with immunosuppressants.After treatment,81.0%of all patients showed improvement or stability while 19.0% showed deterioration or death.The difference of prognosis among three groups was not statistically significant(P >0.05).Conclusion: The detection of myositis autoantibody should be paid more attention in ILD patients.Diagnosis,classification,treatment and prognosis evaluation of ILD could be made with the help of myositis autoantibodies.