Prognostic Analysis Of Patients With Urothelial Carcinoma Of Upper Urinary Tract In Different Parts

Objective: To explore whether there are differences in the prognosis of patients with renal pelvic cancer and ureteral cancer in different stages.Methods: A retrospective analysis of the clinical data of 199 patients diagnosed with upper urinary urothelium in the Department of Urology,First Affiliated Hospital of Chongqing Medical University from 2011 to2018,was divided into renal pelvic cancer group and ureteral cancer group according to the tumor location.The Cox proportional hazard model analyzes the pathological characteristics of patients with recurrence-free survival(RFS),cancer-specific survival(CSS)and overall survival(OS).Kaplan-Meier survival regression curve analysis whether the above characteristics are statistically significant for the prognosis of patients.Results: In the Cox analysis,the pathological grading and staging of tumors can be used as predictors of tumor recurrence and death.There was no statistically significant difference in the location of the primary tumor in RFS,CSS or OS(P= 0.074,0.69,0.75,respectively).In this study,cases were divided into renal pelvic cancer group and ureteral cancer group.The tumor location in Kaplan-Meier survival regression curve analysis did not affect the prognosis of patients(RFS: P=0.148,CSS: P=0.332),while ureteroscopy biopsy reduced the CSS of ureteral cancer(P=0.021).According to Ta+Tis+T1,T2 and T3+T4 stages,upper urinary tract urothelial carcinoma was divided into three subgroups for survival analysis.There is no difference in prognosis between renal pelvic cancer and ureteral cancer in each subgroup.Conclusion: Preoperative ureteroscopy biopsy is more likely to cause cancer-specific death in patients with ureteral cancer,but there is no prognostic difference in the location of the tumor in the upper urinary tract urothelial tumor.Therefore,the location of upper urinary tract urothelial tumors should not be considered as a clinical decision-making factor,and whether patients with suspected ureteral cancer should undergo ureteroscopy biopsy should be carefully determined.