Correlation Analysis Of Perioperative Serum Neuropeptide Y And Substance P Levels With Adverse Cardiovascular Events In Diabetic Patients

Objective:To investigate the correlation between perioperative neuropeptide Y(NPY)and substance P(SP)levels and adverse cardiovascular events.Methods:One hundred and 2 patients of ASA physical status I-II,aged 43～82 years undergoing hip or knee replacement under intrathecal anesthesia were enrolled and assigned to diabetic group(DM,n = 49)and non-diabetic group(NDM,n = 53),according to whether the patients complicated type 2 diabetes mellitus.The two groups of patients were further assigned to four subgroups,i.e.DM with CVD group(DM-CVD),DM not complicating CVD group(DM-NCVD),non-DM with cardiovascular disease(NDM-CVD)and non-DM without cardiovascular disease group(NDM-NCVD).Intraoperative cardiovascular events were recorded and analyzed.Serum concentrations of neuropeptide Y(NPY)and substance P(SP)were determined by ELISA at 30 min before operation,the end of surgery and 24 h after operation.Results:Significant increases in the incidence of intraoperative adverse cardiovascular events and the serum NPY with concomitant lower level of SP were observed in the patients with diabetes,compared with that in non-diabetics(all p < 0.05).Significantly higher level of NPY and lower SP were detected in the diabetic patients complicating cardiovascular disease,when compared with that in diabetic patients not complicating cardiovascular disease(all p < 0.05).Conclusion:The incidence of intraoperative adverse cardiovascular events were closely associated with higher level of serum NPY and lower level of SP.