Construction Of Ca²⁺-doped ZnO Cross-Linked Hydrogel Containing PRP And Its Applications In The Treatment Of Infected Wounds

Chronic wounds secondary to pressure sores,diabetes and venous stasis are always persistent and protracted,mainly due to the susceptibility to bacteria and the undersupply of healing-promoting growth factors.How to solve these problems is the most difficult and the most critical thing.Herein,a new injectable sodium alginate（SA）hydrogel（SZC@PRP）crosslinking by calcium ions(Ca²⁺)doped zinc oxide（ZC）,loading with autogenous platelet-rich plasma（PRP）is proposed.Compared with conventional SA hydrogel,ZC crosslinked SA（SZC）hydrogel not only has improved quality and self-adaptability to irregular wounds,but also has acquired enhanced anti-infection ability.Furthermore,autogenous platelet-rich plasma（PRP）is loaded,which can be persistently activated by ZC,resulting in sustained-release of growth factors.These growth factors,in conjunction with zinc ions(Zn²⁺)and Ca²⁺,jointly promote wound healing through the proliferation of fibroblasts,collagen regeneration and angiogenesis.This is the first application of doping technology prepared ZC in the field of biological hydrogels.As a result,doping technology provides new inspiration for the development of multifunctional hydrogels,and is expected to possess a broader application prospect in coping with more complex and refractory clinical issues.