| Objective:To study the effects of single i TBS on the latency and amplitude of auditory evoked potential(P300),as well as the frequency spectrum and frequency ratio of resting EEG in type 2 diabetes mellitus patients with mild cognitive impairment.This study provides a theoretical basis for the treatment of cognitive function in patients with type 2 diabetes mellitus complicated with mild cognitive impairment by i TBS.Methods:Forty patients with type 2 diabetes mellitus complicated with mild cognitive impairment were randomly divided into two groups:true stimulation group(n=20)and sham stimulation group(n=20).In the real stimulation group,the stimulation site was the left dorsolateral prefrontal cortex,the coil plane was tangent to the scalp at an Angle of 45°,and the handle was backward.Interplexus frequency 5Hz,intra-plexus frequency 50Hz,intermittent 8s every 10s,and stimulation 2s were used.Three 50Hz impulse stimuli were applied every 200ms,and one pulse was sent out every 20ms.Total 190s(600 pulses),the intensity of the stimulus was 80%of the resting motor threshold.In the sham stimulus group,the coil was only perpendicular to the stimulus site.The pulses do not pass through the skull,and the remaining parameters were the same as those in the true stimulus group.Each patient received a 5min resting EEG,audio-evoked event P300 test,and synchronous EEG recording.Then the resting motion threshold was measured with a single pulse,and the two groups were given true or false intermittentθpulses at 80%threshold intensity,respectively.After stimulation,resting EEG and auditory evoked event P300 were recorded again.Results:After the intervention of i TBS,the P300 latency of PZ and CZ in the real stimulation group were respectively(304.60?28.57)ms、(295.80?26.12)ms.compared with before the stimulus to shorten(62.60?12.73)ms,(77.80?13.85)ms,differences were significant statistical significance(P<0.001).Compared with sham stimulation group(355.00?56.74ms),(334.60?58.63)ms,the difference after stimulation was statistically significant(P=0.002,P=0.035).The difference between the two groups showed a statistically significant difference in the central region(Cz)latency(P=0.002).After the intervention of i TBS,there was no significant difference in the absolute power of each electrode channel and each frequency band before and after the intervention of false stimulation group.But true stimulate group after the intervention,compared with before the stimulus,the absoluteβ-band power of T7 and CP6 channels was respectively(45.83?8.28)μV~2、(39.84?11.10)μV~2,,which was statistically significant(P=0.04).The(δ+θ)/(α+β)frequency of T7 channel in the real stimulation group was significantly lower than that before the intervention,with statistical significance(P=0.04).The results of multivariate regression analysis showed that gender,age,body mass index,disease course and absolute power of the subjects had no statistical significance(P>0.05).Conclusion:In patients with type 2 diabetes mellitus complicated with mild cognitive impairment,one session of i TBS can shorten the latency of auditory evoked potential PZ and CZ P300,and improve the response speed of patients.After a single intervention of i TBS,the absolute power ofβ-band of T7 and CP6 channels in the temporal region of type 2 diabetes mellitus patients with mild cognitive impairment was increased,and the frequency ratio of low frequency(δ+θ)to high frequency(α+β)of T7 channels was decreased.i TBS improves cognitive function by affecting cognitive processing in patients with type 2 diabetes with mild cognitive impairment. |
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