Clinical Study Of Autologous Fat Combined With Nano-fat Transplantation On Chronic Wounds Healing

Objective: To investigate the clinical effect of autologous fat combined with nano fat transplantation on chronic wound healing,it provides a new idea for the clinical treatment of chronic wound.Methods: From December 2018 to October 2020,30 cases of chronic wound were selected from the burns and plastic surgery department of Xi’an central hospital,The wound was divided into three parts,intermediate 1 cm not treated as a transitional zone,One side was injected with autologous fat transplantation,the other side was combined with fat and nano fat to the edge and base of the wound,After 7 days,14 days and 28 days,the wound changes were recorded,and the pain degree on both sides of the wound was evaluated by VAS scale,and the patient’s treatment satisfaction was recorded.Results: Of the 30 patients,27 completed follow-up.Two patients died of other diseases unrelated to surgery and one lost follow-up.Among 27 patients,the average wound healing rate of autologous fat cmbined with nano-fat group was higher than that of autologous fat group alone,P<0.001 difference was statistically significant.The VAS scale score of autogenous fat group was significantly higher than that of autogenous fat combined with nano fat group,and P<0.001,the difference was statistically significant.However,there was no significant difference in wound healing rate and VAS scale score of autologous fat group under different etiology;autogenous fat combined with nano-fat group also had no significant difference in wound healing rate and VAS scale score under different etiology,P>0.05 difference was not statistically significant.;Compared with the self-fat group alone,the self-fat group combined with nano-fat group had higher treatment satisfaction,the difference was statistically significant(P<0.05).Conclusion: Using autogenous fat or autogenous fat combined with nano-fat to treat chronic wound can promote wound healing and relieve wound pain;Compared with the autologous fat group alone,autologous fat combined with nano-fat free transplantation has a high rate of wound healing and obvious pain relief,shortens the time of patients in hospital,reduces the cost of hospitalization,lightens the burden of family,and has high satisfaction with patients.It is an ideal new treatment for chronic wounds.