Clinical Observation Of Li Tang Ointment In T2DM Patients With Deficiency Of Qi And Yin Combined With Anxiety State And Its Influence On PPGE

Objective:To compare Li Tang Ointment combined with oral hypoglycemic drugs to treat patients with type 2 diabetes by deficiency of qi and yin in anxiety,by studying its effect on patients’PPGE,FPG,2h-PG,HbA_1c,GA,TC,TG,BMI,TCM syndrome scores and points of generalized anxiety disorder-7 and then verify the clinical efficacy of Li Tang Ointment,provide theoretical basis for further clinical promotion.Methods:72 patients who met the design criterion were collected.According to the principle of random control,they were divided into a control group and a experimental group in a 1:1ratio.The control group was given basic treatments include metformin and acarbose for hypoglycemic treatment.The test group was treated with Li Tang Ointment based on the above basic treatment.After 4 weeks（28 days）of treatment,compare the changes of TCM syndrome scores,PPGE,points of generalized anxiety disorder-7,FPG,2h-PG,HbA_1c,GA,TC,TG,BMI before and after treatment in the two groups,and analyze the correlation between points of generalized anxiety disorder-7 and PPGE,and the correlation between points of generalized anxiety disorder-7 and blood glucose related indicators.Results:1.TCM syndrome scores:The differences in the experimental group before and after treatment was statistically significant（P<0.01）;the differences in the control group before and after treatment was not statistically significant（P>0.05）;the differences between the two groups after treatment was statistically significant（P<0.01）,and the TCM syndrome scores of the experimental group decreased more significantly than that of the control group.2.Generalized anxiety disorder-7（GAD-7）scores:The differences in the experimental group before and after treatment was statistically significant（P<0.01）;the differences between the control group before and after treatment was not statistically significant（P>0.05）;the differences between the two groups after treatment was statistically significant（P<0.01）.The GAD-7 scores of the experimental group has decreased more significantly than that of the control group.3.Postprandial glucose excursion（PPGE）:The differences in the experimental group before and after treatment was statistically significant（P<0.01）;the differences in the control group before and after treatment was statistically significant（P<0.05）;the differences between the two groups after treatment was statistically significant（P<0.01）.PPGE of the experimental group decreased more significantly than the control group.4.Fast plasma glucose（FPG）,2 hours postprandial blood glucose（2h-PG）,Glycosylated hemoglobin(HbA_1c),Glycosylated albumin（GA）:（1）The differences of FPG in the experimental group was statistically significant（P<0.01）,the differences of FPG in the control group before and after treatment was statistically significant（P<0.01）,and the differences between two groups was statistically significant（P<0.01）;（2）The differences of 2h-PG in the experimental group was statistically significant（P<0.01）,the differences of 2h-PG in the control group before and after treatment was statistically significant（P<0.01）,and the differences between two groups was statistically significant（P<0.01）;（3）The differences of HbA1c in the experimental group was not statistically significant（P>0.05）,the differences of HbA1c in the control group before and after treatment was not statistically significant（P>0.05）,and the differences between two groups was not statistically significant（P>0.05）;（4）The differences of GA in the experimental group was statistically significant（P<0.01）,the differences of GA in the control group before and after treatment was statistically significant（P<0.01）,and the differences between two groups was statistically significant（P<0.05）.5.Total triglycerides（TG）,Total cholesterol（TC）and Body mass index（BMI）:（1）The differences of TG before and after treatment in the experimental group was statistically significant（P<0.05）,while the differences of TG before and after treatment in the control group was not statistically significant（P>0.05）,and the differences between the two groups was statistically significant（P<0.05）;（2）The differences of TC before and after treatment in the experimental group was statistically significant（P<0.05）,while the differences of TC before and after treatment in the control group was not statistically significant（P>0.05）,and the differences between the two groups was not statistically significant（P>0.05）;（3）The differences of BMI before and after treatment in the experimental group was not statistically significant（P>0.05）,the differences of BMI before and after treatment in the control group was not statistically significant（P>0.05）,and the differences between the two groups was not statistically significant（P>0.05）.6.Correlation analysis:PPGE is positively correlated with 2h-PG（r=0.448,P=0.000）,positively correlated with HbA1c（r=0.193,P=0.029）,positively correlated with GA（r=0.210,P=0.017）,and positively correlated with TC（r=0.207,P=0.019）,positively correlated with GAD-7 scores（r=0.383,P=0.000）,positively correlated with TCM syndrome scores（r=0.376,P=0.000）,and negatively correlated with BMI（r=-0.2,P=0.024）;GAD-7 scores is positively correlated with FPG（r=0.356,P=0.000）is positively correlated with 2h-PG（r=0.401,P=0.000）,and is positively correlated with HbA_1c（r=0.278,P=0.001）,positive correlation with GA（r=0.361,P=0.000）,positive correlation with PPGE（r=0.383,P=0.000）,positive correlation with TCM syndrome scores（r=0.516,P=0.000）.Conclusion:1.Li Tang Ointment combined with oral hypoglycemic drugs has a certain effect on patients with type 2 diabetes by deficiency of qi and yin in anxiety,which is reflected in the reduction of TCM syndrome scores,GAD-7 scores,PPGE,FPG,2h-PG,GA,TG;2.There is a positive correlation between PPGE and blood glucose levels of T2DM patients with deficiency of qi and yin in anxiety state and GAD-7 scores,which provides a basis for us to control PPGE and blood glucose levels to treat the anxiety of such patients.