| Background and Objective:Type 2 diabetes mellitus has become an important health problem for Chinese.Research shows that the death level of endocrine and metabolic diseases in China does not drop but rises.Some studies have found that the risk of metabolic syndrome shows an upward trend with the increase of 24-hour urinary sodium-potassium ratio.Albuminuria is not only an indicator for early damage of kidney disease,but also related to the increased risk of cardiovascular diseases.In this study,338 patients with type 2 diabetes were selected for clinical data.Cross-sectional study was conducted on the data to observe whether the 24-hour urinary sodium-potassium ratio was correlated with 24-hour albuminuria in patients with type 2 diabetes,so as to explore the risk factors of albuminuria in patients with type 2 diabetes.Methods:In this study,338 patients diagnosed as type 2 diabetes mellitus were hospitalized from July 2019 to Nov.2019 in the Zhu Xianyi Memorial Hospital of Tianjin Medical University.The baseline of the study were obtained from in-patient medical records.According to 24-hour urinary sodium-potassium ratio,it is divided into four group according to quartile.To analyze the related risk factors of albuminuria and the correlation between 24-hour urinary sodium-potassium ratio and albuminuria in patients with type 2 diabetes mellitus.Result:1.A total of 338 patients were included,including 196 male and142 female,84 patients in the low sodium-potassium ratio group(2.68±0.56),85 patients in the middle group(4.00±0.32),85 patients in the high-middle urine group(5.10±0.33),and 84 patients in the high group(7.15±1.10).The proportion of low group was higher than that of women in the high group: low urinary sodium and potassium had lower body weight and smaller waist circumference(p< 0.05).2.the TG of patients in the low urinary sodium-potassium ratio group is lower(p<0.05),and the urine protein in the low urinary sodium-potassium ratio group is lower(p<0.05).3.The body mass index,waist circumference and systolic and diastolic blood pressure of the group with normal urine protein were lower than those of the group with normal urine protein.4.The normal urine protein group has lower TG,higher HDL and lower UA than the others.The ratio of sodium to potassium in normal albuminuria group and microalbuminuria group is lower than that in macroalbuminuria group.5.There was a significant positive correlation between albuminuria and urinary sodium potassium ratio(r=0.176,p=0.001).6.The normal group,microalbuminuria group and macroalbuminuria group were taken as dependent variables,and the 24-hour urinary sodium-potassium ratio,BMI,Hb A1 c,FPG,TG,LDL-c,HDL-c were taken as independent variables for orderly logistics regression analysis.The p value was(OR=1.254,95% CI: 1.087-1.446,p=0.002).The results showed that the 24-hour urinary sodium-potassium ratio was the risk factor of albuminuria.Conclusion:1.In patients with type 2 diabetes mellitus,Urine sodium-potassium ratio may become a risk factor for the occurrence and progression of albuminuria.2.In patients with type 2 diabetes,the high sodium and low potassium intake have adverse effects on the control of metabolic level of diabetes patients.3.Threr are more obese individuals and higher blood pressure in the group of macroalbuminuria,may represent having a greater impact on long-term prognosis and quality of life.4.The increase of albuminuria has worse control over metabolic indexes and has a higher risk of metabolic syndrome.According to the conclusions,it is speculated that the urinary sodium-potassium ratio may affect the metabolic indexes obesity factors and insulin resistance,and affect the albuminuria. |
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