Clinical Observation Of Maxing Decoction In The Treatment Of Respiratory Muscle Fatigue In AECOPD

Objective:Under the guidance of the theory of traditional Chinese medicine,this study used Ma Xing Yin combined with conventional Western medicine therapy to treat respiratory muscle fatigue in the AECOPD.By observing the change of TCM syndrome points,respiratory function-related indicators,the maximum inhaled pressure（MIP）,blood gas analysis results,6-minute walking test（6MWT）,score of auxiliary respiratory muscle use,MRC,acute physiology and chronic health status score（APACHEⅡ）,objectively evaluate the clinical efficacy of Ma Xing Yin on improving AECOPD respiratory muscle fatigue.Methods:A total of 73 patients with chronic obstructive pulmonary disease with acute onset were selected from our hospital who visited between January 2018 and January 2020.The patients were divided into control group and treatment group according to the random number table method,with 36cases in control group and 37 cases in treatment group.Patients in the control group were given conventional symptomatic treatment by Western medicine.Patients in the treatment group were treated with Ma Xing Yin on the basis of conventional western medicine treatment.Both groups were treated for 2weeks.The TCM syndrome score,respiratory function-related indicators,MIP,blood gas analysis results,6MWT,score of auxiliary respiratory muscle use,MRC and APACHEⅡof the two groups of patients were compared before and after treatment.Finally,the clinical efficacy was evaluated by statistical analysis.Results:1.The comparison of TCM syndrome scores between two groups of patients:After treatment,the TCM syndrome scores of both groups of patients were lower than before treatment,the difference was statistically significant（P<0.05）;And the TCM syndrome score of the treatment group was lower than the control group,the difference was statistically significant（P<0.05）,and the effect of the treatment group was better than that of the control group.2.The comparison of respiratory function-related indexes and MIP between the two groups:After treatment,the respiratory function-related indicators and MIP of the two groups were higher than before treatment,and the difference was significant（P<0.05）;And the treatment group had higher indicators than the control group.Among them,the maximum ventilation as a percentage of the predicted value（MVV%）,the ratio of forced expiratory volume to forced vital capacity（FEV₁/FVC）in the first second and MIP index was significantly higher than that before treatment and in patients in the control group,and the difference was significant（P<0.05）,but there is no significant difference in tidal volume as a percentage of predicted value（VC%）（P>0.05）.3.The comparison of blood gas analysis indicators between the two groups:After treatment,the blood gas analysis indicators of the two groups of patients were improved compared with those before treatment,and the difference was significant（P<0.05）;And the improvement of the treatment group was better than that of the control group,The level of partial pressure of blood oxygen（Pa O₂）was significantly higher than that of the control group,and the level of partial pressure of carbon dioxide（Pa CO₂）was significantly lower than that of the control group,and the difference was significant（P<0.05）.4.The comparison of 6-minute walking test between the two groups:After treatment,the 6MWT level of the two groups of patients was higher than before treatment,and the difference was significant（P<0.05）;And after the two groups were compared,the 6MWT level of the treatment group was significantly higher than that of the control group,and the difference was significant（P<0.05）5.The comparison of respiratory muscle related score between the two groups:After treatment,the score of auxiliary respiratory muscle use and MRC of the two groups of patients were lower than before treatment,and the difference was significant（P<0.05）;and after treatment,the two groups were compared,the treatment group was significantly lower than the control group,the difference was significant（P<0.05）.6.The comparison of clinical efficacy of APACHEⅡscores between the two groups:After treatment,the APACHEⅡscores of the two groups were lower than before treatment,and the difference was significant（P<0.05）.And the treatment group was significantly lower than the control group,the difference was significant（P<0.05）7.The comparison of clinical efficacy between the two groups:The total effective rate in the treatment group was 91.42%,which was significantly higher than that in the control group,77.14%,and the difference was significant（P<0.05）.Conclusion:The results of this study indicate that the clinical efficacy of Ma Xing Yin combined with conventional Western medicine therapy for AECOPD respiratory muscle fatigue is effective,which can effectively lower the TCM syndrome points,improve respiratory function,improve blood gas analysis indicators,increase 6MWT levels,lower the score of respiratory muscle related and APACHEⅡ,and improve clinical efficacy,which is worthy of clinical promotion and application.