| Objective:In this study,we compared 30 mg/kg magnesium sulfate before induction of painless gastroscopy anesthesia,and observed hemodynamic parameters,catecholamine concentrations,total propofol,and adverse reactions of magnesium sulfate in patients at different time points And the number of cases requiring intervention during the operation.To investigate the effect of intravenous magnesium sulfate on the stress response of patients with painless gastroscopy,in order to provide some theoretical basis for clinical work.Methods:A total of 60 hospitalized patients were selected for elective painless gastroscopy,aged 40 to 70 years.The patients were randomly divided into two groups:a control group(normal saline,n=30);an experimental group(magnesium sulfate 30mg/kg,n=30),and a magnesium sulfate solution was configured by an assistant.After entering the room,the patient was connected to a monitor for routine heart rate,blood pressure,electrocardiogram,and pulse oxygen saturation monitoring.The patient was placed on the left side,and nasal catheter was used to inhale oxygen(3L/min),and two venous channels were opened.After the above operation is completed,wait for the patient to be emotionally stable for 10 minutes,measure the basic value,draw peripheral venous blood,and mark it as A1.The patient was given an intravenous drip of the completed magnesium sulfate solution(within 15 min),and observed for adverse reactions.Anesthesia was induced by giving dizocine 50 μg/kg,intravenous injection of propofol(1 to 2 mg/kg),and a rate of 4 mg/s.Ramsay sedation score was used to assess the depth of sedation of the patient.When the patient did not respond,the eyelash reflex began to disappear With gastroscopy,propofol was added 0.5mg/kg when the patient was in motion.When the gastroscope probe passes the throat,the peripheral venous blood(non-administrative side)is drawn,marked A2.At the end of the gastroscope and when the patient is conscious(Ramsay score 1～2,can be operated according to instructions),the venous blood(non-giving)Drug side),labeled A3 and A4,respectively.Record the basal state(T0),after the induction is completed(T1),the gastroscope probe passes the throat(T2),the test starts 5min(T3),the test starts 10min(T4),and the end of the test(Ts),Heart rate,mean arterial pressure;noradrenaline and epinephrine concentrations in blood samples taken at time points A1,A2,A3,and A4;record examination time,total postoperative propofol,intraoperative hemodynamics Indicators,the number of cases of adverse reactions after intravenous infusion of magnesium sulfate,and the number of cases requiring intervention during the operation.Results:There was no significant difference in age,body mass index,ASA classification,airway classification,and gastroscopy time between the experimental group and the control group(P>0.05).At T2,compared with the experimental group,the heart rate,systolic pressure,diastolic blood pressure,and mean arterial pressure of the control group were significantly increased,and the differences were statistically significant(P<0.01).At T2,compared with the experimental group,The concentrations of norepinephrine and epinephrine were significantly increased,and the difference was statistically significant(P<0.01).Compared with the experimental group,the number of interventions in the control group was significantly increased,and the difference was statistically significant(P<0.01).Compared with the control group,the total propofol consumption in the experimental group was significantly reduced,and the difference was statistically significant(P<0.01).Conclusion:Intravenous infusion of 30mg/kg magnesium sulfate before the beginning of painless gastroscopy can reduce the body’s stress response,reduce hemodynamic fluctuations,reduce norepinephrine and epinephrine concentrations,and reduce the total amount of propofol used.Increasing the incidence of adverse reactions such as facial flushing and hypotension. |
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