| BackgroundDiabetes is not only a common disease worldwide,but also one of the frequently-occurring diseases in our country.The number of diabetic patients in China ranks first in the world.More than half of the patients have diabetic peripheral neuropathy.Type 2 diabetes mellitus and its peripheral neuropathy have caused a heavy burden on society,economy and individuals.In recent years,more and more studies have focused on the relationship between serum 25-hydroxyvitamin D levels and diabetes and its chronic complications,suggesting that low serum 25-hydroxy vitamin D levels are an important factor leading to the development of diabetes.Vitamin D can reduce the incidence of diabetes,improve the symptoms of patients with type 2 diabetic peripheral neuropathy.These functions of vitamin D are achieved by improving islet function(increasing insulin secretion and sensitivity);reducing oxidative stress and inflammation;regulating immune response;nourishing nerves;improving mental disorders,etc.Contemporary Chinese medicine believes that vitamin D is closely related to the theory of kidney essence in Traditional Chinese Medicine(TCM),and the vitamin D axis can interpret the physiological functions of the kidney system.This study intends to explore the correlation between serum 25-hydroxyvitamin D level and kidney deficiency syndrome in type 2 diabetic peripheral neuropathy,which is very necessary.ObjectiveTo explore the correlation between serum 25-hydroxyvitamin D level and kidney deficiency syndrome in type 2 diabetic peripheral neuropathy.MethodsFrom September 2018 to October 2020,select patients with type 2 diabetic peripheral neuropathy who were hospitalized in the Department of Endocrinology of the Guang’anmen Hospital for patients who meet the conditions of intake and discharge.Telephone follow-up on the scale of the Kidney Deficiency Syndrome Scale and living habits.The patients were divided into two groups based on the diagnostic criteria of kidney deficiency syndrome formulated in the "Guiding Principles for Clinical Research on New Chinese Medicines(2002 Edition)".The results of all test indicators in this study come from the inpatient medical record system of the Endocrinology Department of the Guang’anmen Hospital.After all the original data are entered,the overall situation of the enrolled patients is first analyzed,including general information,laboratory examinations,25-hydroxy vitamin D levels,etc.;then the two groups of patients are compared,including general information,25-Hydroxyvitamin D levels,etc.;then the correlation between 25-hydroxyvitamin D levels and other indicators in the kidney deficiency syndrome group and the non-kidney deficiency syndrome group is tested separately;finally the correlation between 25-hydroxyvitamin D level and other indicators is tested.ResultsA total of 79 patients with type 2 diabetic peripheral neuropathy were enrolled in this study,of which 45 were in the kidney deficiency group and 34 were in the non-kidney deficiency group.1.The overall serum 25-hydroxyvitamin D level in the enrolled patients is low,and many important management goals(such as fasting blood glucose,Hemoglobin A1c,BMI,total cholesterol,low-density lipoprotein,etc.)are not up to standard,and after discharge many patients do not have enough self-management awareness.2.There was no significant difference between the two groups of patients in general qualitative indicators and general quantitative indicators after statistical testing,indicating that the baselines were level and comparable.3.The serum vitamin D level of patients with type 2 diabetic peripheral neuropathy in the kidney-deficiency syndrome group was lower than that in the non-kidney-deficiency syndrome group(P<0.05),suggesting that patients with kidney-deficiency syndrome may have a worse prognosis than those with non-kidney-deficiency syndrome.4.In type 2 diabetic peripheral neuropathy patients with kidney deficiency syndrome,serum vitamin D levels are positively correlated with fasting insulin(P<0.05),but not in the non-kidney deficiency syndrome group(P>0.05);patients in the non-kidney deficiency syndrome group,serum vitamin D was positively correlated with the length of hospitalization(P<0.05),but not in the kidney deficiency group(P>0.05).5.In type 2 diabetic peripheral neuropathy patients with kidney deficiency syndrome,the scores of the kidney deficiency syndrome scale were positively correlated with the length of hospital stay,fasting insulin,blood phosphorus,etc.(P<0.05),but not related to other indicators(P>0.05).ConclusionLow serum 25-hydroxyvitamin D levels are common in patients with type 2 diabetic peripheral neuropathy.Patients with kidney deficiency syndrome are lower than those with non-kidney deficiency syndrome,suggesting that patients with kidney deficiency syndrome may have a worse prognosis than those with non-kidney deficiency syndrome. |
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