| Objective:Membranous nephropathy is an autoimmune disease.Investigations have shown that the prevalence of membranous nephropathy has increased year by year in recent years,especially in Asia.As we all know,PLA2R is the main pathogenic antigen of idiopathic membranousnephropathy,and its susceptibility is related to the PLA2R1 gene locus.This article aims to evaluate the relationship between the two SNPs and IMN.Methods:A systematic search was made in English databases such as Pubmed,Embase,and Chinese databases such as CNKI,Wanfang Database,and China Biomedical Database(CBM)on the susceptibility of rs3749117 and rs3749119 to IMN,respectively.Take odds ratio(OR)and 95%confidence interval(95%CＩ)as the effect size.Through careful and rigorous preliminary screening and re-screening of the literature,literatures related to the subject of this article are selected,and the Newcastle-Ottawa scale is used for literature evaluation,and then data are extracted,and processed and meta-analyzed by stata software.Results:In this article,a total of 7 case-control studies were included.There were 6 sets of original data describing the correlation between the susceptibility of SNP rs3749117 and IMN.There were 1750 cases in the case group and 1593 cases in the control group.Model analysis can find that there is a significant correlation between the susceptibility of rs3749117 and IMN,based on the currently included studies,and the pathogenic gene is T,and C is a protective gene[C/T:OR=0.528,95%CI(0.372～0.749),P<0.001];the risk of idiopathic membranous nephropathy in patients with genotype CT is 1.591 times that of CC genotype[CT/CC:OR=1.591,95%CI(1.194～2.120),P=0.349];The risk of idiopathic membranous nephropathy in patients with genotype TT is 2.956 times that of CC genotype[TT/CC:OR=2.956,95%CI(1.660～5.263),P=0.005];further indicating that the gene T is dominant gene,gene T is a disease-causing gene.However,compared with patients with homozygous TT,the risk of coexisting CC and CT genotypes is greatly reduced[CC+CT/TT:OR=0.509,95%CI(0.326-0.796),P<0.001].Compared with CT+TT patients,the risk of CC homozygous genotype is 0.415 times that of the former.[CC/CT+TT:OR=0.415,95%CI(0.318～0.543),P=0.073].Secondly,6 sets of original data describe the correlation between SNP rs3749119 and IMN susceptibility,and there is also an obvious correlation between rs3749119 and Asian IMN susceptibility.Based on current research,gene C can be considered as a pathogenic gene.,T is a protective gene,and the risk of disease caused by C gene is 2.019 times that of T.gene.[C/T,OR=2.019,95%CI(1.405-2.903),P<0.001;the risk of disease in patients with genotype CT is 1.313 times that of TT type[CT/TT,OR=1.313,95%CI(0.878～1.964),P=0.174];and homozygous genotype CC is 2.491 times that of TT[CC/TT,OR=2.491,95%CI(1.391～4.463),P=0.070];compared with CC,CT Patients with coexistence with TT have a significantly lower risk of disease[CT+TT/CC,OR=0.496,95%CI(0.336-0.732),P=0.012];patients with homozygous TT have a lower risk of disease than patients with CC+CT[TT/CC+CT,OR=0.471,95%CI(0.328,0.676),P=0.143].Conclusion:It can be considered that there is a clear correlation between rs3749119 and rs3749117 and Asian IMN susceptibility.Among them,the pathogenic gene of rs3749119 is C,protect gene is T;the pathogenic gene of rs3749117 is T,protect gene is C. |
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