Neutrophil-to-lymphocyte Ratio In Evaluation Of Inflammation In Non-dialysis Patients With End-stage Renal Disease

Background: Neutrophil-to-lymphocyte ratio(NLR)and have been reported to be associated with inflammation in end-stage renal disease(ESRD)receiving dialysis.However,the value of NLR in non-dialysis patients with ESRD remains unclear.Methods: Among 611 non-dialysis patients with ESRD in The First Affiliated Hospital of University of South China(2012–2018),we compared NLR in patients with high-sensitivity C-reactive protein(hs-CRP)levels of ≤3 mg/L vs.> 3 mg/L.Correlation of NLR to hs-CRP,PCT,ferritin were analyzed.Receiver operating characteristics(ROC)analysis was used for estimating sensitivity and specificity of NLR and PLR.Result: NLR was higher in the patients with high hs-CRP levels(> 3mg/L),compared to patients with low hs-CRP levels(≤ 3 mg/L)[5.74(3.54–9.01)vs.3.96(2.86–5.85),p < 0.0001].In the current study,NLR was positively correlated with hs-CRP(rs = 0.377,p = 0.001),PCT(rs=0.285,p<0.0001),leukocytes(rs=0.510,p<0.0001),neutrophils(rs=0.691,p<0.0001),and platelets(rs=0.100,p=0.015).NLR with a cut-off value of 5.07 indicated sensitivity and specificity were65.67 and 66.37%(AUC = 0.69,95% confidential interval was0.65-0.74).Conclusion: NLR was positively correlated with hs-CRP in non-dialysis patients with ESRD.NLR might be a useful biomark to evaluate inflammation in this population.