Study On The Correlation Between AMH And Gonads,thyroid Hormones And Glucose And Lipid Metabolism Indexes In Patients With Polycystic Ovary Syndrome With Different BMI

Objective:To study the correlation between anti-Mullerian hormone(AMH)and polycystic ovarian syndrome(PCOS)patients with different body mass index(BMI),and the relationship between hormone and glucose and lipid metabolism levels,which is PCOS Provide guidance basis for diagnosis and treatment and intervention of long-term complications.Methods:1.60 patients who were diagnosed with PCOS in the Affiliated Hospital of North Sichuan Medical College from January 2020 to November 2020 were selected and divided into 21 cases of normal body weight(18.5 kg/m2≤BMI<24.0 kg/m2)and 20 cases of overweight weight index(24.0 kg/m2≤BMI<28.0 kg/m2)and 19 cases in the obesity group(28 kg/m2≤BMI).2.Collect the age,height,weight,AMH,serum luteinizing hormone(LH),follicle stimulating hormone(FSH),estradiol(E2),testosterone(T),fasting blood glucose(FPG),fasting insulin(FINS),total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),uric acid,serum free triiodothyronine(FT3),Free Thyroxine(FT4),Hypersensitivity Thyroid Stimulating Hormone(hTSH)and other indicators.Calculate the body mass index(BMI),and calculate the homeostasis model assessment of insulin resistance(HOMA-IR).3.Use SPSS23.0 statistical software to analyze the correlation between AMH and polycystic ovary syndrome patients with different body mass index groups through the statistical methods of variance analysis,Pearson correlation and Spearman correlation,and compare different body mass indexes The differences in AMH,sex hormone levels,glucose and lipid metabolism indexes,and thyroid hormone levels in the group of patients with polycystic ovary syndrome.Results:1.Comparison of various clinical indexes in PCOS patients with different body mass index groups:①FINS and HOMA-IR levels in normal and overweight patients were lower than the obesity group(P<0.05);②TG levels in normal patients were lower than overweight(P<0.05),The HDL-C level of normal patients was higher than that of overweight group(P<0.05);③The obesity and overweight patients had higher uric acid levels than normal group(P<0.05);④AMH level of Normal and overweight patients was higher than that of the obesity group(P<0.05);⑤T level of normal patients was lower than that of overweight group(P<0.05);⑥The levels of FT3,FT4 and hTSH in the three groups of PCOS patients were not significantly different(all P>0.05));2.Correlation between AMH and various clinical indicators in PCOS patients with different body mass index groups:①AMH was negatively correlated with BMI in PCOS patients(P<0.05),and positively correlated with LH、T、and TC in PCOS patients(all P<0.05),and the difference was still statistically significant after the control variable BMI(P<0.05);②The T levels of AMH and PCOS patients in different body mass index groups are positively correlated(P<0.05);③AMH and normal body recombined PCOS patients with TC and LDL-C All were positively correlated(P<0.05).Conclusion:Overweight/obese PCOS patients are more prone to ovulation disorders and abnormal glucose and lipid metabolism than normal recombined PCOS patients.Serum AMH is positively correlated with T in PCOS patients of different body mass index groups,while AMH is negatively correlated with BMI in PCOS patients,suggesting that AMH may become a surrogate marker of high.