Correlation Analysis Of IPTH With Renal Anemia And Cardiac Function In Non-dialysis Patients With Chronic Renal Disease

Objective:With the development of society,the number of people suffering from chronic kidney disease（CKD）has increased significantly.In recent years,some studies have found that the level of total parathyroid hormone（i PTH）may be related to renal anemia and cardiac function.This study aimed at non-dialysis patients in CKD to analyze the relationship between i PTH,anemia and cardiac function.Methods:284 patients with non-dialysis stage 3～5 CKD diagnosed at the Affiliated Hospital of Yanbian University from January 2018 to October 2020 were collected,including 140 males and144 females.According to different levels of i PTH,they were divided into three groups:the first group:i PTH≤150pg/ml;the second group:150pg/ml<i PTH<600pg/ml;the third group:i PTH≥600pg/ml.Clinical data of all patients were collected.Results:1.From January 2018 to October 2020,284 patients with non-dialysis stage 3～5 CKD were diagnosed in the Affiliated Hospital of Yanbian University,There were 28 cases,33 cases and 223cases of CKD stages 3～5,and the number of anemia cases in each stage was 15 cases,23 cases and211 cases respectively,the number of cases of left ventricular hypertrophy（LVH）in each stage was7 cases,10 cases and 112 cases.The incidence of anemia in each stage was 53.6%,69.7%and94.6%,and the incidence of LVH in each stage was 25.0%,30.3%and 50.2%,respectively.2.There were no significant differences in gender,age and body mass index among the three groups（P>0.05）.3.Alkaline phosphatase（ALP）in the group with i PTH≥600pg/ml was higher than that in the group with i PTH≤150pg/ml and the group with i PTH150～600pg/ml,while the serum total cholesterol（TC）and triglyceride（TG）in the group with i PTH≥600pg/ml were lower than those in the other two groups,with statistical differences（P<0.05）.4.Calcium（CA）and carbon dioxide combining power（CO₂CP）decreased successively in the i PTH≤150pg/ml group,i PTH150～600pg/ml group and i PTH≥600pg/ml group.However,phosphorus（P）,serum creatinine（SCr）and blood urea nitrogen（BUN）were increased in turn in i PTH≤150pg/ml group,i PTH150～600pg/ml group and i PTH≥600pg/ml group,that have statistical difference（P<0.05）.5.Hemoglobin（Hb）,red blood cell（RBC）and hematocrit（HCT）in i PTH 150～600pg/ml group and i PTH≥600pg/ml group were lower than those in i PTH≤150pg/ml group,the difference was statistically significant（P<0.05）.Hb in the i PTH≥600pg/ml group was lower than that in the i PTH 150～600pg/ml group,that have statistical difference（P<0.05）.6.Ejection fraction（EF）in i PTH≥600pg/ml group was lower than that in the other two groups,with statistical significance（P<0.05）,The left atrial dimension（LAD）,left ventricular end diastolic dimension（LVEDd）,and left ventricular end systolic dimension（LVDs）in the i PTH 150～600pg/ml group and the i PTH≥600pg/ml group were higher than those in the i PTH≤150pg/ml group.There was statistical difference（P<0.05）.Left ventricular mass index（LVMI）was increased successively in the i PTH≤150pg/ml group,150～600pg/ml group,and i PTH≥600pg/ml group,with statistical difference（P<0.05）.7.Correlation analysis showed that i PTH was positively correlated with P,SCr,BUN and LVMI（P<0.001）.i PTH was negatively correlated with Hb and Hct（P<0.001）.Conclusion:1.i PTH was negatively correlated with Hb and Hct in CKD stage 3～5 patients.2.There was a positive correlation between i PTH and P,Scr and BUN in CKD stage 3～5patients.3.There was a positive correlation between i PTH and LVMI in CKD stage 3～5 patients.