Relationship Between Serum Magnesium Levels And Prognosis Of Peritoneal Dialysis Patients

BackgroundChronic kidney disease is a growing global disease,the global prevalence of 11-13%,it can eventually progress to end-stage renal disease(ESRD).Hemodialysis(HD)and peritoneal dialysis(PD)are the main renal replacement therapy for patients with ESRD[1].Due to its convenience,safety and effectiveness,peritoneal dialysis is not only suitable for urban residents,especially for the vast rural and remote areas in China,and has become the main alternative treatment method.The diffusion,convection and ultrafiltration of peritoneal membrane are the principles of peritoneal dialysis,which aims to remove toxic substances of large and small molecules in the body,correct acidbase imbalance and electrolyte disorder,and remove excessive water as a kidney replacement therapy method.Peritoneal dialysis is simple and easy to operate.It is effective in removing some medium molecular substances,occupying few medical resources,protecting residual renal function and having little impact on the internal environment.Therefore,it is a better choice for the prognosis of some patients with cardiovascular instability,old patients and young uremia patients.However,lifestyle changes in PD patients are also a key issue.In recent years,maintenance of fluid balance and dynamic balance between internal environment ions are also considered to be decisive factors affecting the efficacy of PD.Therefore,this paper studies the influence of serum magnesium ions on the prognosis of PD patients.In Europe,the impact of low serum magnesium in patients with end-stage peritoneal dialysis has been confirmed that patients with low serum magnesium ions increase peritoneal dialysis,the risk of hospitalization and death.The purpose of this study was to investigate the relationship between serum magnesium content and prognosis of peritoneal dialysis patients in central China.ObjectiveBy analyzing the prognosis of peritoneal dialysis patients with different magnesium ion levels,we can provide stable monitoring standards for the ion level and internal environment of peritoneal dialysis patients,so as to improve the treatment level of peritoneal dialysis patients.MethodsA total of 418 patients with end-stage renal disease who underwent peritoneal dialysis at the First Affiliated Hospital of Zhengzhou University for more than 3 months from September 2012 to January 2019 were selected and divided into three groups based on the serum magnesium level in our hospital.<=0.7mmol/L,called Hypomagnesia group;0.7-<1.1mmol/L was the normal magnesium ion group;>1.1mmol/L group was high magnesium group,and general clinical baseline indicators were collected for all patients,including gender,age,and BMI.Laboratory indicators included blood electrolytes,serum albumin,serum creatinine,blood triglycerides,blood cholesterol,and estimated glomerular filtration rate.The survival time and outcome of patients in the three groups were followed up and recorded,as well as the risk factors affecting the survival outcome of peritoneal dialysis.Results1.In this study,the baseline data were divided into three groups based on serum magnesium.Finally,it was concluded that the differences among the three groups of serum electrolyte calcium,phosphorus and potassium were of significant significance,which was related to the metabolism of magnesium ions in the body and serum calcium,phosphorus and potassium to jointly maintain the stability of the internal environment.2.Of the 418 PD patients,131(31.3%)withdrew from PD,of which 29 died,73 transferred to hemodialysis,24 received kidney transplantation,and 5 patients were lost to follow-up.The frequency of peritonitis with low serum magnesium was 0.3,0.18 in normal serum magnesium ion group,and 0.15 in high serum magnesium group.3.There was no significant difference between lower,normal and high serum magnesium(p>0.05).4.COX regression analysis also confirmed the impact of risk and age of albuminemia on survival in PD patients(p<0.05).ConclusionSerum magnesium ion is closely related to plasma of serum calcium,phosphorus and potassium in maintaining the stability of the internal environment of PD patients.Low serum magnesium ion is associated with a higher rate of infection in PD patients and is not an independent risk factor for survival in PD patients.Hypoalbuminemia is an independent risk factor for survival in PD patients.