Study On Relationship Between Thyroid Hormones,Thyroid Autoantibodies And Renal Function In Patients With Graves’ Disease

Background and Objective:Graves’ disease is a common clinical disease that can damage multiple human systems.At present,there are many studies on complications such as hyperthyroidism liver damage and hyperthyroidism heart disease,but there are few studies on kidney injury of hyperthyroidism.At present,some studies have analyzed the correlation between thyroid function and some indicators of renal function.However,the effect of thyroid function on all indicators of renal function has not been reported.And there have been no reports at home and abroad to analyze the effects of thyroid autoantibodies on various indicators of renal function and related mechanisms.In this study,in order to investigate the effects of thyroid hormones and thyroid autoantibodies on renal function in patients with Graves’ disease,thyroid hormones,thyroid autoantibodies and renal function related indexes were compared between Graves’ disease patients and healthy subjects,the thyroid hormones,thyroid autoantibodies and renal function related indexes in Graves patients of different genders and healthy people of different genders were compared.and the correlation between thyroid hormones,thyroid autoantibodies and renal function indexes were analyzed in patients with Graves’ disease.Patients and Methods:1.PatientsA total of 329 patients with Graves’ disease and hyperthyroidism admitted to the Department of Endocrinology of the First Affiliated Hospital of Zhengzhou University from January 2019 to December 2020 were selected and assigned to the hyperthyroidism group,including 227 female patients and 102 male patients.At the same time,89 cases of healthy people in our hospital were selected as the healthy control group,including 53 cases of female and 36 cases of male.2.MethodsThe data were collected including the test results of thyroid function,renal function and thyroid autoantibody of the subjects.SPSS21.0 statistical software was used to analyze the data.The t test was used to compare the measurement data of the two groups with normal distribution,while the rank sum test was used to compare the data with skewed distribution.Spearman correlation analysis of urea,creatinine,uric acid,GFR,Cys-C,β2-MG with FT3,FT4,TSH,TPOAB,TGAB,TRAB,TSAB was performed,and both were tested by bilateral test.P<0.05 indicated statistically significant differences.Results:1.The levels of urea,uric acid,GFR,FT3,FT4 and cystatin C,β2-microglobulin in hyperthyroidism group were significantly higher than those in control group(P<0.05),and the levels of creatinine and TSH in hyperthyroidism group were significantly lower than those in control group(P<0.05).2.FT3 and FT4 in hyperthyroidism group were negatively correlated with creatinine(P<0.05),and positively correlated with uric acid,GFR,cystatin C andβ2-microglobulin(P<0.05).TSH was positively correlated with creatinine(P<0.05),and negatively correlated with uric acid,GFR,cystatin C and a32-microglobulin(P<0.05).TPOAB was positively correlated with uric acid,GFR and β2microglobulin(P<0.05).TGAB was negatively correlated with urea and creatinine(P<0.05),and positively correlated with GFR and β2-microglobulin(P<0.05).TRAB was negatively correlated with creatinine(P<0.05),and positively correlated with uric acid and GFR(P<0.05).TSAB was negatively correlated with creatinine(P<0.05),and positively correlated with uric acid,GFR,cystatin C andβ2-microglobulin(P<0.05).3.The levels of urea,creatinine and uric acid in male patients with hyperthyroidism were significantly higher than those in female patients(P<0.05),but there were no statistically significant differences in GFR,cystatin C,β2-microglobulin,FT3,FT4,TSH,TGAb,TPOAb,TRAB and TSAB between male and female patients(P>0.05).4.The levels of urea,creatinine and uric acid in men in the healthy control group were significantly higher than those in women(P<0.05),but there were no statistically significant differences in GFR,cystatin C,β2-microglobulin,FT3,FT4 and TSH between them(P>0.05).Conclusion:1.There was no significant difference in GFR levels between the patients with Graves’ disease and the healthy control group.2.Elevated thyroid hormone levels in Graves’ disease patients may increase the levels of uric acid,GFR,cystatin C,β2 microglobulin,and decrease the level of creatinine.3.Thyroid autoantibodies may affect renal function through changes in thyroid hormones or through immune mechanisms.