Analysis Of Clinical Characteristics Of Patients With COVID-19 In Different Severity Classification

[Purpose] To improve the ability of early identification of severe patients with COVID-19 by studying the clinical characteristics and laboratory characteristics of different severity.[Methods] A retrospective analysis of clinical and laboratory features of 138 patients diagnosed with COVID-19 admitted to Liyuan Hospital,affiliated to Tongji Medical College Huazhong University of Science and Technology from January 14,2020 to February 8,2020 was divided into 3 groups including regular,severe,critically ill according to the severity of the patients’ conditions.The t test was used to compare the differences between the groups.Chi-square test was used to compared between the regular group and the severe / critically ill group.Pearson correlation analysis was performed for the correlation analysis of main inflammatory factors and organ function damage indicators.[Results] Among the 138 patients,the age was(58.57 ± 16.49)years;45.65% were males and 54.35% were females;the highest temperature during the course of the disease was(38.67 ± 0.78)°C,the duration of intermittent fever was(10.05 ± 6.19)days,and the length of hospital stay(9.00 ± 5.51)days;regular type was 45.65%,severe type was33.33%,and critically ill type was 21.01%.There were significant differences in neutrophils,lymphocytes,monocytes,high-sensitivity C-reactive protein,and lactate dehydrogenase in the regular group compared with the severe group(P < 0.05).There were significant differences in neutrophils,lymphocytes,hypersensitive C-reactive protein,alanine aminotransferase,lactate dehydrogenase,D-D dimer,serum troponin T and creatine kinase isoenzyme MB type(P < 0.05).Platelet,hypersensitivity-C-reactive protein,procalcitonin,lactate dehydrogenase,myoglobin,troponin T were significantly different between the severe group and the critically ill group(P < 0.05).Between the regular group and the severe / critically ill group,gender and the co-infection were not significantly different between the two groups of patients,and age and underlying diseases were significantly different between the two groups of patients.Pearson correlation analysis showed that lymphocyte counts and hypersensitivity C responses protein and alanine aminotransferase are moderately related to aspartate aminotransferase,the correlation coefficients are-0.41 and 0.49,and alanine aminotransferase was strongly related to creatine kinase and lactate dehydrogenase,the correlation coefficients are 0.94 and 0.93.[Conclusions] Changes of blood lymphocytes,platelets,centroblasts,myocardial injury indicators,hypersensitive-C reactive protein,DD dimer,lactate dehydrogenase,liver function injury indicators,age,previous underlying diseases and body temperature in patients with COVID-19 is closely related to the severity of the patient’s condition.Among them,the progressive increase of hypersensitivity-C reactive protein and lactate dehydrogenase may be an early warning indicator of the aggravation of patients with new coronary pneumonia;age and underlying diseases are important factors for the progression of new coronary pneumonia patients to severe / critical.