| Objective: To investigate the activity characteristics of plasma protein C and protein S in patients with acute pulmonary thromboembolism(APTE),and explore its correlation with pulmonary thromboembolism and clinical value;to improve clinicians’ understanding of APTE primary risk factors and the APTE diagnostic rate,guide the course of anticoagulant therapy,improve the efficacy and prognosis.Methods: Forty-seven patients diagnosed with APTE by CTPA(CT pulmonary angiography)who were hospitalized in the First Affiliated Hospital of Guangxi Medical University from May 2017 to May 2020 were selected as the observation group(APTE group);twenty healthy subjects in the physical examination center of our hospital were selected as the control group.Taking 50 years old as the boundary,the observation group was divided into Group A(18-49 years old)and Group B(≥50 years old),The observation group was divided into female group and male group according to gender.According to the presence or absence of DVT,the patients were divided into simple APTE group and APTE combined DVT group.According to risk stratification,it is divided into four groups: low-risk group,middle-low-risk group,middle-high-risk group and high-risk group.The activity of PC was detected by chromogenic substrate method,the activity of PS was detected by coagulation method.We use SPSS20.0 software for data processing and statistical analysis.Results:(1)The activities of PC and PS in APTE patients were lower than the healthy group,the detection rate of deficiency were higher than the healthy group,these differences were statistically significant(P<0.05).(2)Comparison of PC activity in the APTE group: there was a statistically significant difference in PC activity between the simple APTE group and the combined lower extremity DVT group(P<0.05);these differences between the same age group and different gender groups,between the same gender and different age groups were not statistically significant(P>0.05);the high-risk group was lower than the low-risk group,the middle-low-risk group,and the middle-high-risk group was lower than the low-risk group,these differences were statistically significant(P<0.05).(3)Comparison of PS activity in the APTE group: there was not statistically significant difference in PS activity between the simple APTE group and the combined lower extremity DVT group(P>0.05);the female group A(18-49 years old)was lower than the female group B(≥50 years old),the difference is statistically significant(P<0.05);there were not statistically significant differences between the male group A(18-49 years old)and the male group B(≥50 years old),the male group and the female same age group(P> 0.05);the high-risk group was lower than the low-risk group,the middle-low-risk group,and the middle-high-risk group was lower than the middle-low-risk group,and the low-risk group was lower than the middle-low-risk group,these differences were statistically significant(P<0.05).(4)The detection rate of deficiency in APTE group: there was not significant difference between the simple APTE group and the combined lower extremity DVT group(P >0.05);the different detection rates of deficiency of PC and PS at different risk levels were statistically significant(P<0.05),and there were linear growth trends(P<0.05).(5)In the APTE group,PC and PS activities were negatively correlated with PTE risk(P <0.05).Conclusion:(1)The PC and PS deficiency rates of APTE patients in this group were 19.1% and 27.7%,which were consistent with some domestic reports and higher than foreign literature reports.(2)The PC and PS activity levels of APTE patients are lower than the normal control group,suggesting that the anticoagulant protein deficiency plays an important role in the process of venous thrombosis.(3)The PC and PS in APTE patients are related to the risk degree of the disease,the lower activity levels,the higher risk degree of illness will be.Plasma PC and PS activity levels can help predict APTE risk degree to a certain extent. |
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