Effect Of Dexmedetomidine On Postoperative Bowl Function Of Patients Who Underwent Transabdominal Resection Of Rectal Cancer

Objective: To investigate the effect of dexmedetomidine on postoperative bowel function in patients of rectal cancer who underwent laparoscopic transabdominal resection of rectal cancer.Methods: A total of 62 patients who needed intravenous anesthesia and inhalation anesthesia combined with epidural anesthesia to underwent laparoscopic transabdominal resection of rectal cancer were randomly divided into two groups(31 patients in each group).ASA is II～ III,aged from 40 to78 years old,male to female ratio was similar,weight: 40～80kg.C group was infused with equivalent saline and D group was infused with dexmedetomidine0.5μg /kg/h till 40 minutes before the end of the operation.Patients in group C continued infused of equal volume of normal saline,but group D continued infusion of dexmedetomidine 0.5μg / kg / h intravenous.After punctured lumbar epidural successful,placed catheter into epidural space to relieve pain perioperation.Anesthesia induced by propofol,remifentanil,fentanyl,cis-atracurium.Propofol,remifentanil,ropivacaine,cis-atracurium to maintain BIS values within 40～60,and blood pressure was maintained within 20% of the preoperative basal level.Stoped sevoflurane 30 minutes before the end of the operation.Five min before the end of the operation,propofol and remifentanil were stopped,and tropisetron and fentanyl were given then delivered the patients to the PACU.Measurements related data such as dosage of propofol,remifentanil,fentanyl,ropivacaine.Operation time,volume of bleeding,volume of urine,potassium ion concentration and Hb of artery before left PACU and the first anal exhaust time postoperation,and the first feeding time postoperation were recorded.Results: There was no significant difference in sex,age,BMI,ASA(P>0.05).There was no significant difference in operation time,volume of bleeding,volume of urine,potassium ion concentration and Hb of artery(P>0.05).differences in propofol,remifentanil,fentanyl,ropivacaine dosage were not statistically significant(P>0.05).The time of the first postoperative anal exhaustion and the time of the first postoperative fluid intake in group D were shorter than those in group C(P<0.05).There was no significant difference in the time of first postoperative defecation time(P> 0.05).Conclusion: Dexmedetomidine is beneficial to the recovery of bowel function after laparoscopic assisted transabdominal rectal cancer resection under intravenous inhalation combined with epidural anesthesia.