The Ordered Construction And Antibacterial Properties Of Antibacterial Particles On Nanofibers

In recent years,the composite of functional particles and nanofibers by electrospinning has gradually become a research hotspot of antibacterial materials.Different forms of antibacterial fibers have different antibacterial properties.Although the process of electrospinning inorganic nanoparticles dispersed in the spinning solution is simple,the antibacterial fibers with random distribution of functional nanoparticles are obtained,and the utilization efficiency is not high when the nanoparticles are wrapped in the fibers.Although the common impregnation or spraying can make the nanoparticles adhere to the fiber surface,it will cause the uneven distribution of nanoparticles or poor adhesion.In view of the above shortcomings,this paper proposes three processes to make the nanoparticles on the surface of the fiber uniform and orderly construction,better play the antibacterial effect of functional nanoparticles.The main research contents are as follows:1.Firstly,ZnO/graphene oxide(ZnO/GO)composite nanomaterials were prepared in hydrothermal environment.The characterization results show that ZnO nanoparticles are uniformly distributed in hexagonal wurtzite crystal form with two-dimensional GO lamellae as growth anchor.Compared with the composites with different GO content,it is determined that the size of ZnO nanoparticles is the smallest when the GO content is 10%.Then,the ZnO/GO nanocomposites were dispersed uniformly on the surface of the gelatin by electrospinning and electrospray.The fiber was characterized by SEM,EDX,XRD and FTIR to determine the micro morphology and composition of the fiber.Finally,E.coli and S.aureus were selected to test the antibacterial activity of the fiber.The results showed that the antibacterial rate of the composite antibacterial fiber was more than 90%,and the antibacterial mechanism was summarized and analyzed.2.Organic polymer composite fibers with SiO2 precursor as core and zinc salt as shell were prepared by micro-control of solution properties and spinning parameters of inner and outer layers of coaxial electrospinning.Then,SiO2 fibers with 3D nano network structure were obtained by gradient calcination,and ZnO nanoparticles were uniformly constructed on them.This in-situ formation method can realize the uniform and ordered distribution of ZnO in the micro finite element.SEM,EDX,XRD and FTIR were used to characterize the micro morphology,composition and crystal structure of the fiber,and then the antibacterial test was carried out.The antibacterial activity of the fibers with the highest ZnO content to E.coli and S.aureus was 88.0%and 79.7%respectively.3.In order to avoid the damage of high temperature treatment to biomaterials,we continuously adjust the solution properties and spinning parameters of core-shell spinning solution based on the instantaneous nano preparation technology and the reaction between microfluidic interfaces,so as to solve the problem of interface reaction between core-shell spinning solution and realize the rapid reaction between zinc salt in shell and core-shell alkaline solution while stretching into fibers,The precursor of ZnO/gelatin nanofibers was prepared.Finally,ZnO/gelatin composite fibers were obtained by subsequent treatment.SEM,EDX,FTIR and XRD were used to confirm the existence of ZnO on the fiber surface and the antibacterial activity of the fiber.At the same time,it provides research ideas and scientific guidance for the formation of nanoparticles on the fiber surface under relatively mild conditions.